Title:
AMIDE COMPOUND, COMPOSITION CONTAINING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/001307
Kind Code:
A1
Abstract:
An amide compound of formula (I), a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate, or a solvate thereof, a pharmaceutical composition containing the compound, and a pharmaceutical use thereof. The compound and the pharmaceutical composition have excellent protein kinase inhibitory activity and good pharmacokinetic properties, can increase drug concentrations of the compound in animals, and improve the efficacy and safety of the drug.
Inventors:
WANG YIHAN (CN)
ZHAO JIUYANG (CN)
ZHAO JIUYANG (CN)
Application Number:
PCT/CN2018/091829
Publication Date:
January 03, 2019
Filing Date:
June 19, 2018
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D417/12; A61K31/4035; A61K31/427; A61P3/00; A61P9/00; A61P31/12; A61P35/00; A61P37/00; C07D209/34
Domestic Patent References:
| WO2007143434A2 | 2007-12-13 | |||
| WO2009080694A1 | 2009-07-02 | |||
| WO2017004383A1 | 2017-01-05 |
Other References:
JIA, YONG ET AL.: "Overcoming EGFR(T790M) and EGFR(C797S) Resistance with Mutant- Selective Allosteric Inhibitors", NATURE, vol. 534, 25 May 2016 (2016-05-25), pages 129 - 132, XP055342543, ISSN: 0028-0836
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682 - 684, XP008173943, ISSN: 1672-7738
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682 - 684, XP008173943, ISSN: 1672-7738
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