Title:
AMIDE DERIVATIVE COMPOUND, STEREOISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL OR COSMETIC COMPOSITION COMPRISING SAME FOR SUPPRESSING SKIN AGING, RELIEVING WRINKLES, OR HEALING SKIN WOUNDS
Document Type and Number:
WIPO Patent Application WO/2018/101793
Kind Code:
A3
Abstract:
Provided are an amide derivative compound or a stereoisomer, derivative, solvate, or pharmaceutically acceptable salt thereof, and a use thereof according to an aspect. According to the present invention, a composition of the present invention has excellent effects of increasing the expression of Sirt1 and healing skin wounds and suppressing skin aging by the activation of Sirt1, and thus can be favorably used as a pharmaceutical composition for suppressing skin wounds and skin aging or relieving wrinkles. In addition, the composition can be favorably used in anti-aging or skin wrinkle relief by reducing the amount of MMP-1 secretion, increasing the amount of procollagen type I secretion, and increasing the amount of Sirt1 secretion and activity of Sirtl in skin fibroblasts induced by ultraviolet irradiation.
Inventors:
KIM SANG HEE (KR)
KIM SUN YEOU (KR)
KIM SUN YEOU (KR)
Application Number:
PCT/KR2017/014019
Publication Date:
July 19, 2018
Filing Date:
December 01, 2017
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV GACHON IND ACAD COOP FOUND (KR)
UNIV GACHON IND ACAD COOP FOUND (KR)
International Classes:
A61K31/4402; A61K8/49; A61K31/4168; A61K31/505; A61Q19/08; C07D241/20; C07D263/48
Domestic Patent References:
| WO2003049702A2 | 2003-06-19 |
Other References:
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DATABASE CAS [O] 1 June 2016 (2016-06-01), retrieved from STN Database accession no. 1922572-11 -9
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DATABASE CAS [O] 1 April 2004 (2004-04-01), retrieved from STN Database accession no. 669701-60-4
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DATABASE CAS [O] 3 February 2009 (2009-02-03), retrieved from STN Database accession no. 1099967-41 -5
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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