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Title:
AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/158204
Kind Code:
A1
Abstract:
The present invention relates to amide derivatives and pharmaceutically acceptable salts thereof, preparation method therefor and medicinal application thereof. Specifically, the present invention relates to amide derivatives represented by general formula (I), preparation method therefor, pharmaceutical compositions containing the derivatives, and use thereof as therapeutic agent, especially as inhibitor for microsomal prostaglandin E synthase-1(mPGES-1), and use in preparation of medicines for treating and/or preventing diseases or illness such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.

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Inventors:
LI XIN (CN)
HE WEI (CN)
LIU XIANBO (CN)
WANG BIN (CN)
HU QIYUE (CN)
JIN FANGFANG (CN)
DONG QING (CN)
SUN PIAOYANG (CN)
Application Number:
PCT/CN2015/075531
Publication Date:
October 22, 2015
Filing Date:
March 31, 2015
Export Citation:
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Assignee:
SHANGHAI HENGRUI PHARM CO LTD (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D401/12; A61K31/4035; A61K31/404; A61K31/416; A61K31/423; A61K31/4355; A61K31/437; A61K31/4439; A61P1/00; A61P1/02; A61P1/18; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/04; A61P11/06; A61P13/08; A61P13/12; A61P17/06; A61P19/02; A61P25/02; A61P25/06; A61P25/18; A61P25/28; A61P29/00; A61P31/16; A61P35/00; A61P35/02; C07C233/47; C07C233/63; C07D209/08; C07D209/10; C07D209/44; C07D213/78; C07D213/80; C07D231/56; C07D263/57; C07D405/04; C07D405/12; C07D405/14; C07D413/12; C07D471/04
Domestic Patent References:
WO2013118071A12013-08-15
WO2013038308A12013-03-21
WO2013072825A12013-05-23
Foreign References:
CN101490000A2009-07-22
Other References:
See also references of EP 3133068A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
北京戈程知识产权代理有限公司 (CN)
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