Title:
AMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2003/086377
Kind Code:
A1
Abstract:
Drugs for potentiating the therapeutic effect against cancers, the mechanisms of action of which drugs involve DNA damage, containing compounds represented by the general formula (I) or salts thereof as the active ingredient: (I) wherein one of R1 and R2 is hydrogen and the other is -X-A (wherein A is hydrogen or acyl; and X is oxygen or NH); and one of R3 and R4 is hydrogen and the other is a group represented by the general formula (II): (II) (wherein Y is sulfonyl or carbonyl; R5 is a cyclic group; Z is a single bond or C1-4 alkylene; and R6 is hydrogen or C1-6 alkyl).
Inventors:
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
ITAI AKIKO (JP)
Application Number:
PCT/JP2003/004986
Publication Date:
October 23, 2003
Filing Date:
April 18, 2003
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
International Classes:
A61K31/166; A61K31/167; A61K31/18; A61K31/22; A61K31/255; A61K31/341; A61K31/36; A61K31/407; A61K31/4184; A61P35/00; A61P43/00; C07D213/42; C07D235/14; C07D235/10; (IPC1-7): A61K31/18; A61K31/166; A61K31/167; A61K31/22; A61K31/255; A61K31/341; A61K31/36; A61K31/407; A61K31/4184; A61K45/00; A61P35/00; A61P43/00; C07D235/14; C07D307/52; C07D317/58
Foreign References:
| JP2001504492A | 2001-04-03 | |||
| US5399487A | 1995-03-21 | |||
| US5707985A | 1998-01-13 | |||
| GB827446A | 1960-02-03 | |||
| JPH03217459A | 1991-09-25 | |||
| JPS4830733A | 1973-04-23 | |||
| JPH05503721A | 1993-06-17 | |||
| JPH06504052A | 1994-05-12 |
Other References:
DESAI R.D.: "Studies in sulphonamides: Part IV. Some N6-heterocyclic sulphonamides from 2-naphthylamine as possible antibacterial agents", JOUR. INDIAN CHEM. SOC., vol. 46, no. 5, 1969, pages 411 - 415, XP002969906
FUJITA SATOSHI: "Fluorescent substrates for potential use in enzyme-linked immunosorbent assay of membrane-bound nucleic acids", ANALYTICAL CHEMISTRY, vol. 66, no. 8, 1994, pages 1347 - 1353, XP002969907
FUJITA SATOSHI: "Fluorescent substrates for potential use in enzyme-linked immunosorbent assay of membrane-bound nucleic acids", ANALYTICAL CHEMISTRY, vol. 66, no. 8, 1994, pages 1347 - 1353, XP002969907
Attorney, Agent or Firm:
SIKS & CO. (8th Floor 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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