Title:
AMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2015/129860
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent useful in the treatment and/or prevention of conditions, including cancer, caused by enhanced OPN production, the therapeutic agent containing a compound represented by the formula (in the formula, R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification) or a pharmaceutically acceptable salt thereof.
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Inventors:
KIKUCHI HARUHISA (JP)
OSHIMA YOSHITERU (JP)
HATTORI TOSHIO (JP)
KUBOHARA YUZURU (JP)
YAMADA OSAMU (JP)
ZHANG JING (JP)
MATSUSHITA YOSHIHISA (JP)
KIDA SHINYA (JP)
OSHIMA YOSHITERU (JP)
HATTORI TOSHIO (JP)
KUBOHARA YUZURU (JP)
YAMADA OSAMU (JP)
ZHANG JING (JP)
MATSUSHITA YOSHIHISA (JP)
KIDA SHINYA (JP)
Application Number:
PCT/JP2015/055873
Publication Date:
September 03, 2015
Filing Date:
February 27, 2015
Export Citation:
Assignee:
UNIV TOHOKU (JP)
UNIV GUNMA NAT UNIV CORP (JP)
FUSO PHARMACEUTICAL IND (JP)
UNIV GUNMA NAT UNIV CORP (JP)
FUSO PHARMACEUTICAL IND (JP)
International Classes:
C07C235/50; A61K31/165; A61K31/166; A61K31/351; A61K31/4045; A61K31/437; A61P1/16; A61P9/10; A61P11/00; A61P13/04; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07C233/36; C07C233/62; C07C233/78; C07C235/48; C07C235/60; C07C237/22; C07C237/42; C07D209/14; C07D213/81; C07D309/08
Domestic Patent References:
| WO2006016218A1 | 2006-02-16 | |||
| WO2013063492A1 | 2013-05-02 | |||
| WO2010028192A1 | 2010-03-11 | |||
| WO2011035143A2 | 2011-03-24 | |||
| WO2007003934A2 | 2007-01-11 | |||
| WO2011032291A1 | 2011-03-24 |
Foreign References:
| JPS49101348A | 1974-09-25 | |||
| JP2011512321A | 2011-04-21 | |||
| CN102320989A | 2012-01-18 | |||
| JP2012505855A | 2012-03-08 | |||
| JP2003128639A | 2003-05-08 | |||
| JP2010540633A | 2010-12-24 | |||
| JP2007506777A | 2007-03-22 |
Other References:
HARUHISA KIKUCHI ET AL.: "Isolation and Synthesis of a New Aromatic Compound, Brefelamide, from Dictyostelium Cellular Slime Molds and Its Inhibitory Effect on the Proliferation of Astrocytoma Cells", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 70, no. 22, 2005, pages 8854 - 8858, XP055221527
ANTONIO ENTRENA ET AL.: "Kynurenamines as Neural Nitric Oxide Synthase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 26, 2005, pages 8174 - 8181, XP055221529
BYOUNGHO MOON ET AL.: "Structure and Bioactivity of Erebusinone, a Pigment from the Antarctic Sponge Isodictya erinacea", TETRAHEDRON, vol. 56, no. 46, 2000, pages 9057 - 9062, XP004238563
MARLENE T. BARHO ET AL.: "N-Acyl Derivatives of 4-Phenoxyaniline as Neuroprotective Agents", CHEMMEDCHEM, vol. 9, no. 10, October 2014 (2014-10-01), pages 2260 - 2273, XP055221531
EVGENIJA DJURENDIC ET AL.: "Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives", ARKIVOC, 2011, pages 83 - 102, XP055137317
SHIN'YA MURASE ET AL.: "Saibosei Nenkin Yurai Kagobutsu brefelamide to sono Yudotai no Osteopontin Hatsugen Yokusei Sayo", THE PHARMACEUTICAL SOCIETY OF JAPAN TOHOKU SHIBU TAIKAI KOEN YOSHISHU, vol. 53, 5 October 2014 (2014-10-05), pages 30, XP008184695
See also references of EP 3112343A4
ANTONIO ENTRENA ET AL.: "Kynurenamines as Neural Nitric Oxide Synthase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 26, 2005, pages 8174 - 8181, XP055221529
BYOUNGHO MOON ET AL.: "Structure and Bioactivity of Erebusinone, a Pigment from the Antarctic Sponge Isodictya erinacea", TETRAHEDRON, vol. 56, no. 46, 2000, pages 9057 - 9062, XP004238563
MARLENE T. BARHO ET AL.: "N-Acyl Derivatives of 4-Phenoxyaniline as Neuroprotective Agents", CHEMMEDCHEM, vol. 9, no. 10, October 2014 (2014-10-01), pages 2260 - 2273, XP055221531
EVGENIJA DJURENDIC ET AL.: "Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives", ARKIVOC, 2011, pages 83 - 102, XP055137317
SHIN'YA MURASE ET AL.: "Saibosei Nenkin Yurai Kagobutsu brefelamide to sono Yudotai no Osteopontin Hatsugen Yokusei Sayo", THE PHARMACEUTICAL SOCIETY OF JAPAN TOHOKU SHIBU TAIKAI KOEN YOSHISHU, vol. 53, 5 October 2014 (2014-10-05), pages 30, XP008184695
See also references of EP 3112343A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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