Title:
AMIDINO COMPOUNDS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2001072702
Kind Code:
A3
Abstract:
The present invention relates to amidino compounds of formula (I), in which the variables are as defined in the claims, and salts thereof. In another embodiment the present invention also provides a use of the present compounds as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods for making the amidino compounds and other compounds (I).
Inventors:
WEBBER RONALD KEITH
Application Number:
PCT/US2001/009431
Publication Date:
September 19, 2002
Filing Date:
March 23, 2001
Export Citation:
Assignee:
PHARMACIA CORP (US)
WEBBER RONALD KEITH
WEBBER RONALD KEITH
International Classes:
A61K31/198; A61K31/4166; A61K31/4245; A61P1/02; A61P1/04; A61P1/16; A61P3/00; A61P1/00; A61P3/08; A61P3/10; A61P7/06; A61P9/00; A61P9/02; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P15/08; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/06; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/06; A61P39/02; A61P43/00; C07C317/48; C07C317/50; C07C323/58; C07C323/59; C07D233/76; C07D271/06; C07D271/07; C07D277/56; (IPC1-7): C07C323/58; C07C317/48; C07D271/06; C07D233/76; C07C323/59; A61K31/155; A61P29/00
Foreign References:
| US5981511A | 1999-11-09 |
Other References:
R.J. YOUNG, ET AL.: "Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 6, March 2000 (2000-03-01), Elsevier Science Publishers, Amsterdam, NL, pages 597 - 600, XP004190946, ISSN: 0960-894X
W. RIED, ET AL.: "Amidinosäuren und imidopeptide", CHEMISCHE BERICHTE, vol. 95, no. 3, March 1962 (1962-03-01), Verlag Chemie, Weinheim, DE, pages 728 - 732, XP002174896, ISSN: 0009-2940
U.K. SAHA, ET AL.: "Synthesis of new glycopeptidomimetics based on N-substituted oligoglycine bearing an N-linked lactoside side-chain", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 24, 21 December 1995 (1995-12-21), Royal Society of Chemistry, Letchworth, GB, pages 2571 - 2573, XP002174897, ISSN: 0022-4936
W. KÖNIG, ET AL.: "Neue S-Schutzgruppen für Cystein", CHEMISCHE BERICHTE, vol. 101, no. 2, 1 February 1968 (1968-02-01), Verlag Chemie, Weinheim, DE, pages 681 - 693, XP002174898, ISSN: 0009-2940
C. DUGAVE, ET AL.: "Synthesis of natural and non natural orthogonally protected lanthionines from N-tritylserine and allo-threonine derivatives", TETRAHEDRON: ASYMMETRY, vol. 8, no. 9, 8 May 1997 (1997-05-08), Elsevier Science Publishers, Amsterdam, NL, pages 1453 - 1465, XP004064108, ISSN: 0957-4166
G. PATTENDEN, ET AL.: "Enantioselective synthesis of 2-alkyl substituted cysteines", TETRAHEDRON, vol. 49, no. 10, 5 March 1993 (1993-03-05), Elsevier Science Publishers, Amsterdam, NL, pages 2131 - 2138, XP002174899, ISSN: 0040-4020
N.G. KIMPE, ET AL.: "Novel syntheses of 5-acetyl-2,3-dihydro-1,4-thiazine, a very intense roasty, popcornlike odorant", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 46, no. 6, 29 May 1998 (1998-05-29), American Chemical Society, Washington, DC, US, pages 2278 - 2281, XP002174900, ISSN: 0021-8561
W. RIED, ET AL.: "Amidinosäuren und imidopeptide", CHEMISCHE BERICHTE, vol. 95, no. 3, March 1962 (1962-03-01), Verlag Chemie, Weinheim, DE, pages 728 - 732, XP002174896, ISSN: 0009-2940
U.K. SAHA, ET AL.: "Synthesis of new glycopeptidomimetics based on N-substituted oligoglycine bearing an N-linked lactoside side-chain", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 24, 21 December 1995 (1995-12-21), Royal Society of Chemistry, Letchworth, GB, pages 2571 - 2573, XP002174897, ISSN: 0022-4936
W. KÖNIG, ET AL.: "Neue S-Schutzgruppen für Cystein", CHEMISCHE BERICHTE, vol. 101, no. 2, 1 February 1968 (1968-02-01), Verlag Chemie, Weinheim, DE, pages 681 - 693, XP002174898, ISSN: 0009-2940
C. DUGAVE, ET AL.: "Synthesis of natural and non natural orthogonally protected lanthionines from N-tritylserine and allo-threonine derivatives", TETRAHEDRON: ASYMMETRY, vol. 8, no. 9, 8 May 1997 (1997-05-08), Elsevier Science Publishers, Amsterdam, NL, pages 1453 - 1465, XP004064108, ISSN: 0957-4166
G. PATTENDEN, ET AL.: "Enantioselective synthesis of 2-alkyl substituted cysteines", TETRAHEDRON, vol. 49, no. 10, 5 March 1993 (1993-03-05), Elsevier Science Publishers, Amsterdam, NL, pages 2131 - 2138, XP002174899, ISSN: 0040-4020
N.G. KIMPE, ET AL.: "Novel syntheses of 5-acetyl-2,3-dihydro-1,4-thiazine, a very intense roasty, popcornlike odorant", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 46, no. 6, 29 May 1998 (1998-05-29), American Chemical Society, Washington, DC, US, pages 2278 - 2281, XP002174900, ISSN: 0021-8561
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