Title:
AMIDOPYRIDINOL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2014/171801
Kind Code:
A1
Abstract:
The present invention relates to an amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising an amidopyridinol derivative or a pharmaceutically acceptable salt thereof as an active component. An amidopyridinol derivative represented by chemical formula 1 or a pharmaceutically acceptable salt thereof has an excellent antiangiogenic effect in a chorioallantoic membrane model and is thus useful as an agent for preventing or treating diseases associated with angiogenesis, such as macular degeneration or arthritis, and also has an excellent colitis-inhibitory effect in a model of inflammatory bowel disease and is thus useful as an agent for preventing or treating inflammatory bowel diseases. Upon inoculation of lung cancer cells in a chorioallantoic membrane model, the amidopyridinol derivative represented by chemical formula 1 or a pharmaceutically acceptable salt thereof inhibits angiogenesis caused by tumorigenesis and tumor growth, and also inhibits the activity of cathepsin S which plays an important role in metastasis or invasion of cancer and thus is useful as an inhibitor of cancer growth and metastasis.
Inventors:
JEONG BYEONG SEON (KR)
KIM JUNG AE (KR)
NAM TAE GYU (KR)
LEE HYUN JI (KR)
KIM DONG GUK (KR)
KANG YOU RA (KR)
BEEN JAE HUI (KR)
JIN YOU JIN (KR)
REGMI SUSHIL CHANDRA (KR)
GAUTAM JAYA (KR)
KIM JUNG AE (KR)
NAM TAE GYU (KR)
LEE HYUN JI (KR)
KIM DONG GUK (KR)
KANG YOU RA (KR)
BEEN JAE HUI (KR)
JIN YOU JIN (KR)
REGMI SUSHIL CHANDRA (KR)
GAUTAM JAYA (KR)
Application Number:
PCT/KR2014/003450
Publication Date:
October 23, 2014
Filing Date:
April 21, 2014
Export Citation:
Assignee:
UNIV YEUNGNAM RES COOPERATION FOUNDATION (KR)
International Classes:
C07D213/75; A61K31/4402; A61P29/00; A61P35/00
Domestic Patent References:
| WO2009012283A1 | 2009-01-22 |
Foreign References:
| US20010039344A1 | 2001-11-08 |
Other References:
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SERWA, REMIGIUSZ ET AL.: "Preparation and Investigation of Vitamin B6-Derived Aminopyridinol Antioxidants", CHEMISTRY - A EUROPEAN JOURNAL, vol. 16, no. 47, 2010, pages 14106 - 14114, XP055071904
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KOCH AE, ATRHRITIS. RHEUM., vol. 41, no. 6, 1998, pages 951 - 962
JEFFREY MI ET AL., J. CLIN. INVEST., vol. 103, 1999, pages L231 - 1236
ADAMIS AP ET AL., ANGIOGENESIS, vol. 3, 1999, pages 9 - 14
FOLKMAN J, J. INVEST. DERMATOL., vol. 59, 1972, pages 40 - 48
FOLKMAN; TYLER: "Biologic mechanisms and Therapy", 1977, RAVEN PRESS, article "Cancer Invasion and metastasis,", pages: 94 - 103
POLVERINI PJ, CRIT. REV. ORAL. BIOL. MED., vol. 6, no. 3, 1995, pages 230 - 247
REISER J ET AL., J CLIN INVEST, vol. 120, no. 10, 2010, pages 3421 - 31
GORMLEY JA ET AL., BR J CANCER, vol. 105, no. 10, 2011, pages 1487 - 94
FAN Q ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 425, no. 4, 2012, pages 703 - 10
HENRY JA ET AL., CANCER, vol. 65, no. 2, 1990, pages 265 - 71
JOHNSON MD ET AL., CANCER RES., vol. 53, no. 4, 1993, pages 873 - 7
NGUYEN M ET AL., MICROVASCULAR RES., vol. 47, 1994, pages 31 - 40
SERWA, REMIGIUSZ ET AL.: "Preparation and Investigation of Vitamin B6-Derived Aminopyridinol Antioxidants", CHEMISTRY - A EUROPEAN JOURNAL, vol. 16, no. 47, 2010, pages 14106 - 14114, XP055071904
D'AMATO RJ ET AL., OPHTHALMOLOGY, vol. 102, no. 9, 1995, pages L261 - 1262
ARBISER JL, J. AM. ACAD. DERMATOL., vol. 34, no. 3, 1996, pages 486 - 497
O'BRIEN KD ET AL., CIRCULATION, vol. 93, no. 4, 1996, pages 672 - 682
HANAHAN D ET AL., CELL, vol. 86, 1996, pages 353 - 364
KOCH AE ET AL., ARTHRITIS. RHEUM., vol. 29, 1986, pages 471 - 479
STUPACK DG; BRAZ J. ET AL., MED. BIOL. RCS., vol. 32, no. 5, 1999, pages 578 - 581
KOCH AE, ATRHRITIS. RHEUM., vol. 41, no. 6, 1998, pages 951 - 962
JEFFREY MI ET AL., J. CLIN. INVEST., vol. 103, 1999, pages L231 - 1236
ADAMIS AP ET AL., ANGIOGENESIS, vol. 3, 1999, pages 9 - 14
FOLKMAN J, J. INVEST. DERMATOL., vol. 59, 1972, pages 40 - 48
FOLKMAN; TYLER: "Biologic mechanisms and Therapy", 1977, RAVEN PRESS, article "Cancer Invasion and metastasis,", pages: 94 - 103
POLVERINI PJ, CRIT. REV. ORAL. BIOL. MED., vol. 6, no. 3, 1995, pages 230 - 247
REISER J ET AL., J CLIN INVEST, vol. 120, no. 10, 2010, pages 3421 - 31
GORMLEY JA ET AL., BR J CANCER, vol. 105, no. 10, 2011, pages 1487 - 94
FAN Q ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 425, no. 4, 2012, pages 703 - 10
HENRY JA ET AL., CANCER, vol. 65, no. 2, 1990, pages 265 - 71
JOHNSON MD ET AL., CANCER RES., vol. 53, no. 4, 1993, pages 873 - 7
NGUYEN M ET AL., MICROVASCULAR RES., vol. 47, 1994, pages 31 - 40
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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