AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES

WIPO Patent Application WO/2007/069712

A1

Disclosed is a novel amine compound represented by the general formula (I) below, a pharmaceutically acceptable acid addition salt of the compound, or a hydrate or solvate of the compound or the salt, which is excellent in an immunosuppressing effect, a rejection response-suppressing effect and the like and is reduced in adverse side effects such as bradycardia. Also disclosed is a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. (I) wherein R represents a hydrogen atom or P(=O)(OH)2; X represents an oxygen or sulfur atom; Y represents CH2CH2 or CH=CH; R1 represents an alkyl having 1-4 carbon atoms which is substituted by a halogen atom or a cyano; R2 represents an alky having 1-4 carbon atoms which may be substituted by a hydroxyl group or a halogen atom; R3 and R4 independently represent a hydrogen atom or an alkyl having 1-4 carbon atoms; and n represents 5-8.

KIUCHI MASATOSHI (JP)
MARUKAWA KAORU (JP)
KOBAYASHI NOBUTAKA (JP)
SUGAHARA KUNIO (JP)

PCT/JP2006/325016

June 21, 2007

December 15, 2006

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MITSUBISHI PHARMA CORP (JP)
KIUCHI MASATOSHI (JP)
MARUKAWA KAORU (JP)
KOBAYASHI NOBUTAKA (JP)
SUGAHARA KUNIO (JP)

C07C217/64; A61K31/137; A61K31/165; A61K31/222; A61K31/277; A61K31/325; A61K31/351; A61K31/357; A61K31/661; A61K31/675; A61K31/695; A61P3/10; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P27/16; A61P29/00; A61P37/02; A61P37/06; C07C255/59; C07C323/32; C07C323/43; C07F9/09

WO1996006068A1	1996-02-29
WO1994008943A1	1994-04-28
WO2004110979A2	2004-12-23
WO2004024673A1	2004-03-25
WO2004110421A1	2004-12-23
WO2006011554A1	2006-02-02

See also references of EP 1961734A4
None

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