AMINE COMPOUNDS AND USE THEREOF - KUREHA CHEMICAL IND CO LTD

Title:

AMINE COMPOUNDS AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2004/024697

Kind Code:

A1

Abstract:

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1): (1) In a typical case, A₁ and A₂ represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C_3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH₂, C(=O) or NR₁₁; and D is a group represented by the following general formula (4) or (6). or (4) -Q-Y-B (6) In the formula (6), Q represents a single bond, S, O or NR₁₂; and Y is a group represented by the following general formula (7). -(CR₁₈R₁₉)m₃- or -(CR₂₀R₂₁)m₄-z-(CR₂₂R₂₃)m₅- (7) z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents -NR₂₅R₂₆. In the above formulae, R₁ to R₂₆ each represents hydrogen, alkyl, alkenyl or alkynyl.

Inventors:

YAMAZAKI TORU (JP)
KIKUMOTO SHIGEYUKI (JP)
ONO MASAHIRO (JP)
SAITOU ATSUSHI (JP)
TAKAHASHI HARUKA (JP)
KUMAKURA SEI (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
TAKEMURA YOSHIYUKI (JP)
SUZUKI SHIGERU (JP)
MATSUI RYO (JP)

Application Number:

PCT/JP2003/011381

Publication Date:

March 25, 2004

Filing Date:

September 05, 2003

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KUREHA CHEMICAL IND CO LTD (JP)
YAMAZAKI TORU (JP)
KIKUMOTO SHIGEYUKI (JP)
ONO MASAHIRO (JP)
SAITOU ATSUSHI (JP)
TAKAHASHI HARUKA (JP)
KUMAKURA SEI (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
TAKEMURA YOSHIYUKI (JP)
SUZUKI SHIGERU (JP)
MATSUI RYO (JP)

International Classes:

A61P19/06; A61P31/12; A61P35/04; C07D233/54; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D417/12; C07D417/14; (IPC1-7): C07D233/02; C07D401/12; C07D401/14; C07D403/12; C07D417/12; C07D413/12; C07D409/14; C07D403/14; C07D405/14; C07D417/14; C07D413/14; A61K31/4439; A61K31/454; A61K31/4178; A61K31/496; A61K31/4709; A61K31/427; A61K31/4184; A61K31/4725; A61K31/497; A61K31/433; A61K31/422; A61K31/4196; A61K31/5513; A61K31/5415; A61K31/428; A61K31/498; A61K31/517; A61K31/55

Domestic Patent References:

WO2001010842A2

2001-02-15

Foreign References:

US6096773A	2000-08-01
EP0628551A1	1994-12-14

Other References: