Title:
AMINE DERIVATIVES AND SKIN PREPARATIONS FOR EXTERNAL USE CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2000/017152
Kind Code:
A1
Abstract:
Amine derivatives represented by general formula (1) and preparations for external use containing the same which exhibit excellent effects of preventing the skin from aging, etc. In formula (1), R?1¿ represents C¿1-30? hydrocarbyl optionally interrupted by an ether linkage (but excluding phenyl and benzyl); one of A and B represents (2), while the other represents -OR?4¿; R?2¿ and R?3¿ represent each H, amidino, alkanoyl, C¿1-20? hydrocarbyl, etc. and R?4¿ and R?5¿ represent each H, phosphoryl, etc.
Inventors:
FUJIMORI TAKETOSHI (JP)
OHASHI YUKIHIRO (JP)
HIGUCHI KAZUHIKO (JP)
ISHIKAWA JUNKO (JP)
KITAHARA TAKASHI (JP)
OHASHI YUKIHIRO (JP)
HIGUCHI KAZUHIKO (JP)
ISHIKAWA JUNKO (JP)
KITAHARA TAKASHI (JP)
Application Number:
PCT/JP1999/005141
Publication Date:
March 30, 2000
Filing Date:
September 21, 1999
Export Citation:
Assignee:
KAO CORP (JP)
FUJIMORI TAKETOSHI (JP)
OHASHI YUKIHIRO (JP)
HIGUCHI KAZUHIKO (JP)
ISHIKAWA JUNKO (JP)
KITAHARA TAKASHI (JP)
FUJIMORI TAKETOSHI (JP)
OHASHI YUKIHIRO (JP)
HIGUCHI KAZUHIKO (JP)
ISHIKAWA JUNKO (JP)
KITAHARA TAKASHI (JP)
International Classes:
A61K8/41; A61K8/43; A61K8/49; A61Q19/08; C07C217/28; C07C219/06; C07C229/12; C07C233/18; C07C279/08; C07C291/04; C07D263/24; C07D295/088; C07F9/09; (IPC1-7): C07C217/28; C07C219/06; C07C279/08; C07C291/04; C07F9/09; C07D263/20; C07D295/08; A61K31/495; A61K31/40; A61K31/13
Domestic Patent References:
| WO1991014688A1 | 1991-10-03 |
Foreign References:
| US4609659A | 1986-09-02 |
Other References:
ROUSH WILLIAM R. ET AL.: "Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine", J. ORG. CHEM., vol. 50, no. 20, 1985, pages 3752 - 3757, XP002925877
BONGINI ALESSANDRO ET AL.: "A new approach to (+/-)-2-amino-2-deoxytetritol derivatives", J. CHEM. SOC., PERKIN TRANS. 1, 1985, pages 935 - 939, XP002925878
MCCOMBIE S.W. ET AL.: "Cyclofunctionalization reactions of epoxy alcohol derivatives. 3. Cyclisation-acyl migration of N-benzoylcarbamates to stereodefined oxazolidinones. A new, diastereospecific route to thiamphenicol", TETRAHEDRON LETT., vol. 28, no. 45, 1987, pages 5395 - 5398, XP002925879
CARDILLO GIULIANA ET AL.: "Oxazolidin-2-ones from allylic amines by means of iodine and carbonate anion on polymeric support. A convenient synthesis of (+/-)-propranolol", J. ORG. CHEM., vol. 51, no. 5, 1986, pages 713 - 717, XP002925880
BONGINI ALESSANDRO ET AL.: "A new approach to (+/-)-2-amino-2-deoxytetritol derivatives", J. CHEM. SOC., PERKIN TRANS. 1, 1985, pages 935 - 939, XP002925878
MCCOMBIE S.W. ET AL.: "Cyclofunctionalization reactions of epoxy alcohol derivatives. 3. Cyclisation-acyl migration of N-benzoylcarbamates to stereodefined oxazolidinones. A new, diastereospecific route to thiamphenicol", TETRAHEDRON LETT., vol. 28, no. 45, 1987, pages 5395 - 5398, XP002925879
CARDILLO GIULIANA ET AL.: "Oxazolidin-2-ones from allylic amines by means of iodine and carbonate anion on polymeric support. A convenient synthesis of (+/-)-propranolol", J. ORG. CHEM., vol. 51, no. 5, 1986, pages 713 - 717, XP002925880
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku, Tokyo, JP)
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