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Title:
AMINE SOLVATE OF SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/190568
Kind Code:
A1
Abstract:
Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

Inventors:
ZHANG, Lei (No. 16, Lane 67 Libing Road Pilot Free Trade Zone, Shanghai 3, 201203, CN)
WANG, Yuan (No. 16, Lane 67 Libing Road Pilot Free Trade Zone, Shanghai 3, 201203, CN)
Application Number:
CN2017/078309
Publication Date:
November 09, 2017
Filing Date:
March 27, 2017
Export Citation:
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Assignee:
YOUNGENE THERAPEUTICS CO., LTD. (No. 16, Lane 67 Libing Road Pilot Free Trade Zone, Shanghai 3, 201203, CN)
International Classes:
C07H9/04; A61K31/7048; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07H1/00
Domestic Patent References:
WO2015032272A12015-03-12
WO2015027963A12015-03-05
Foreign References:
CN101056853A2007-10-17
CN104513283A2015-04-15
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (David W. Cheng, Level 19 Tower E3, The Towers, Oriental Plaza,,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, 100738, CN)
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