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Title:
AMINE SOLVATE OF SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/190568
Kind Code:
A1
Abstract:
Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

Inventors:
ZHANG LEI (CN)
WANG YUAN (CN)
Application Number:
CN2017/078309
Publication Date:
November 09, 2017
Filing Date:
March 27, 2017
Export Citation:
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Assignee:
YOUNGENE THERAPEUTICS CO LTD (201203, CN)
International Classes:
C07H9/04; A61K31/7048; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07H1/00
Domestic Patent References:
WO2015032272A12015-03-12
WO2015027963A12015-03-05
Foreign References:
CN101056853A2007-10-17
CN104513283A2015-04-15
Other References:
See also references of EP 3453712A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (David W. Cheng, Level 19 Tower E3, The Towers, Oriental Plaza,,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, 100738, CN)
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