Title:
AMINO ACID-BASED WATER-BASED LIQUID, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/065882
Kind Code:
A1
Abstract:
An amino acid-based multifunctional water-based liquid, a preparation method therefor and a use thereof. In the water-based liquid, water is used as a solvent, and viscous droplets rich in amino acids, oligopeptides or/and amino acid/oligopeptide derivatives and having a particle size of 0.05-100 μm are dispersed in the water-based liquid. The amino acid-based water-based liquid does not contain any organic solvent, features a simple composition, good biocompatibility, ecological recycling, wide material source and low costs, can be used as a green solvent, a cell cryopreservation solution, a protein preservation solution, a micro enzymatic reactor and a biomedical adhesive of various active substances, and has wide application prospects.
Inventors:
YAN XUEHAI (CN)
YUAN CHENGQIAN (CN)
XING RUIRUI (CN)
YUAN CHENGQIAN (CN)
XING RUIRUI (CN)
Application Number:
PCT/CN2022/125108
Publication Date:
April 04, 2024
Filing Date:
October 13, 2022
Export Citation:
Assignee:
INST PROCESS ENG CAS (CN)
International Classes:
C07K5/00; A01N1/02; A61L24/00; C07K14/805; C12P3/00; C12P17/10
Domestic Patent References:
| WO2020058329A1 | 2020-03-26 |
Foreign References:
| US20190388357A1 | 2019-12-26 | |||
| US20120251633A1 | 2012-10-04 | |||
| CN106333922A | 2017-01-18 |
Other References:
ABBAS MANZAR, LIPIŃSKI WOJCIECH P., WANG JIAHUA, SPRUIJT EVAN: "Peptide-based coacervates as biomimetic protocells", CHEMICAL SOCIETY REVIEWS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 50, no. 6, 29 March 2021 (2021-03-29), UK , pages 3690 - 3705, XP093008096, ISSN: 0306-0012, DOI: 10.1039/D0CS00307G
CHENGQIAN YUAN; AVIAD LEVIN; WEI CHEN; RUIRUI XING; QIANLI ZOU; THERESE W. HERLING; PAVAN KUMAR CHALLA; TUOMAS P. J. KNOWLES; XUEH: "Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 58, no. 50, 7 November 2019 (2019-11-07), Hoboken, USA, pages 18116 - 18123, XP072088478, ISSN: 1433-7851, DOI: 10.1002/anie.201911782
BARTOSZ GABRYELCZYK: "Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 10, no. 1, UK, XP093153863, ISSN: 2041-1723, DOI: 10.1038/s41467-019-13469-8
CHENGQIAN YUAN; AVIAD LEVIN; WEI CHEN; RUIRUI XING; QIANLI ZOU; THERESE W. HERLING; PAVAN KUMAR CHALLA; TUOMAS P. J. KNOWLES; XUEH: "Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 58, no. 50, 7 November 2019 (2019-11-07), Hoboken, USA, pages 18116 - 18123, XP072088478, ISSN: 1433-7851, DOI: 10.1002/anie.201911782
BARTOSZ GABRYELCZYK: "Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 10, no. 1, UK, XP093153863, ISSN: 2041-1723, DOI: 10.1038/s41467-019-13469-8
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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