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Title:
AMINO ACID DERIVATIVE HAVING RENIN INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/1992/016497
Kind Code:
A1
Abstract:
Compounds represented by general formulae (I), (II) and (III), wherein compound (I) is useful as a renin inhibitor, while compounds (II) and (III) are intermediates for the production thereof.

Inventors:
Shibata, Saizo (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Yamada, Yasuki (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Tada, Hiroki (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Tsuji, Hiroyuki (Toxicology Research Laboratories of Japan Tobacco Inc, 23 Nakog, Hadano-shi Kanagawa 257, JP)
Uchida, Itsuo (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Nakamura, Ikuro (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
Hayashi, Yoshiharu (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
Ikegami, Kiyoteru (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
Application Number:
PCT/JP1992/000329
Publication Date:
October 01, 1992
Filing Date:
March 18, 1992
Export Citation:
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Assignee:
JAPAN TOBACCO INC. (12-62, Higashishinagawa 4-chome Shinagawa-ku, Tokyo 140, JP)
YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (6-9 Hiranomachi 2-chome, Chuo-ku Osaka-shi, Osaka 541, JP)
Shibata, Saizo (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Yamada, Yasuki (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Tada, Hiroki (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Tsuji, Hiroyuki (Toxicology Research Laboratories of Japan Tobacco Inc, 23 Nakog, Hadano-shi Kanagawa 257, JP)
Uchida, Itsuo (Pharmaceutical Research Laboratories of Japan Tobacco Inc, 6-2 Umegaoka, Midori-k, Yokohama-shi Kanagawa 227, JP)
Nakamura, Ikuro (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
Hayashi, Yoshiharu (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
Ikegami, Kiyoteru (Yoshitomi Pharmaceutical Industries Ltd, Central Research Laboratories, 7-25, Koyata 3-chom, Iruma-shi Saitama 358, JP)
International Classes:
C07C271/16; C07C323/60; C07D209/30; C07D209/34; C07D217/26; C07D233/54; C07D235/24; C07D263/06; C07D295/15; C07D319/06; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07D471/04; C07D487/04; (IPC1-7): A61K31/40; A61K31/42; A61K31/47; A61K31/52; C07C237/22; C07D207/27; C07D209/30; C07D209/60; C07D217/26; C07D263/16; C07D263/18; C07D263/34; C07D263/36; C07D263/60; C07D319/06; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D471/04; C07D471/14; C07D473/00; C07D487/04
Foreign References:
JPS6463559A1989-03-09
JPS63275552A1988-11-14
Attorney, Agent or Firm:
Takashima, Hajime (Yuki Building, 3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka 541, JP)
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