Title:
AMINO ACID DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1993/024448
Kind Code:
A1
Abstract:
An amino acid derivative represented by general formula (I), a pharmacologically acceptable salt thereof, and a cancer metastasis inhibitor containing the same, wherein L?1¿ and L?2¿ represent each an amino acid residue, etc.; A?1¿ and A?3¿ represent each C=O; A?2¿ represents alkylene, etc.; m and n represent each an integer of 1 to 5; V represents -NHC(=NH)NH¿2?, etc.; W represents -COOH, etc.; R?1¿ and R?2¿ represent each hydrogen, alkyl, etc.; R?3¿ and R?4¿ represent each hydrogen, etc.; and X and Y represent each -NH- or -O-. The derivative has a potent effect of inhibiting cancer metastasis and is reduced in the activity of inhibiting platelet agglutination and the anticoagulant activity.
Inventors:
NISHIKAWA NAOYUKI (JP)
ORIKASA ATSUSHI (JP)
KOMAZAWA HIROYUKI (JP)
KOJIMA MASAYOSHI (JP)
SAIKI IKUO (JP)
AZUMA ICHIRO (JP)
ORIKASA ATSUSHI (JP)
KOMAZAWA HIROYUKI (JP)
KOJIMA MASAYOSHI (JP)
SAIKI IKUO (JP)
AZUMA ICHIRO (JP)
Application Number:
PCT/JP1993/000734
Publication Date:
December 09, 1993
Filing Date:
June 01, 1993
Export Citation:
Assignee:
FUJI PHOTO FILM CO LTD (JP)
NISHIKAWA NAOYUKI (JP)
ORIKASA ATSUSHI (JP)
KOMAZAWA HIROYUKI (JP)
KOJIMA MASAYOSHI (JP)
SAIKI IKUO (JP)
AZUMA ICHIRO (JP)
NISHIKAWA NAOYUKI (JP)
ORIKASA ATSUSHI (JP)
KOMAZAWA HIROYUKI (JP)
KOJIMA MASAYOSHI (JP)
SAIKI IKUO (JP)
AZUMA ICHIRO (JP)
International Classes:
A61K31/195; A61K31/22; A61K38/00; A61P35/00; A61P43/00; C07C233/47; C07C237/12; C07C279/14; C07C279/20; C07D251/52; C07K5/02; C07K5/06; C07K5/072; (IPC1-7): C07C233/47; A61K31/195; A61K31/22; C07C237/22; C07C279/14; C07D251/52
Domestic Patent References:
| WO1992013552A1 | 1992-08-20 |
Foreign References:
| JPH04334349A | 1992-11-20 | |||
| JPS61243052A | 1986-10-29 | |||
| JPH02174789A | 1990-07-06 | |||
| US5100875A | 1992-03-31 |
Other References:
See also references of EP 0644181A4
SCIENCE, vol. 233, 1986, pages 467
INT. J. BIOL. MACROMOL., vol. 11, 1989, pages 23
INT. J. BIOL. MACROMOL., vol. 11, 1989, pages 226
JPN. J. CANCER RES., vol. 60, 1989, pages 722
THROMBOSIS AND HEMOSTASIS, vol. 58, 1987, pages 2133
JPN. J. CANCER RES., vol. 60, 1989, pages 722
THROMBOSIS AND HEMOSTASIS, vol. 58, 1987, pages 2133
SCIENCE, vol. 233, 1986, pages 467
INT. J. BIOL. MACROMOL., vol. 11, 1989, pages 23
INT. J. BIOL. MACROMOL., vol. 11, 1989, pages 226
JPN. J. CANCER RES., vol. 60, 1989, pages 722
THROMBOSIS AND HEMOSTASIS, vol. 58, 1987, pages 2133
JPN. J. CANCER RES., vol. 60, 1989, pages 722
THROMBOSIS AND HEMOSTASIS, vol. 58, 1987, pages 2133
Attorney, Agent or Firm:
Nakamura, Minoru (Shin-Tokyo Bldg. 3-1, Marunouchi 3-chom, Chiyoda-ku Tokyo 100, JP)
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