Title:
AMINO ACID-DERIVED DIAMINOPROPANOLS
Document Type and Number:
WIPO Patent Application WO1996001788
Kind Code:
A3
Abstract:
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
Inventors:
PAL BIMAN (US)
RAM SIYA (US)
CAI BING (US)
SACHDEVA YESH P (US)
SHIM JAECHUL (US)
ZAHR SALAH A (US)
AL-FARHAN EMILE (US)
GABRIEL RICHARD (US)
RAM SIYA (US)
CAI BING (US)
SACHDEVA YESH P (US)
SHIM JAECHUL (US)
ZAHR SALAH A (US)
AL-FARHAN EMILE (US)
GABRIEL RICHARD (US)
Application Number:
PCT/US1995/008411
Publication Date:
March 28, 1996
Filing Date:
July 05, 1995
Export Citation:
Assignee:
PHARM ECO LAB INC (US)
PAL BIMAN (US)
RAM SIYA (US)
CAI BING (US)
SACHDEVA YESH P (US)
SHIM JAECHUL (US)
ZAHR SALAH A (US)
AL FARHAN EMILE (US)
GABRIEL RICHARD (US)
PAL BIMAN (US)
RAM SIYA (US)
CAI BING (US)
SACHDEVA YESH P (US)
SHIM JAECHUL (US)
ZAHR SALAH A (US)
AL FARHAN EMILE (US)
GABRIEL RICHARD (US)
International Classes:
C07C213/00; C07C213/02; C07C215/30; C07C227/16; C07C229/02; C07C269/06; C07C271/16; C07C271/20; C07C273/18; C07D207/08; C07D207/09; C07D207/12; C07C215/18; C07C275/14; (IPC1-7): C01C269/06; C07C271/16; C07D207/12; C07D207/08; C07C271/20; C07C215/28
Foreign References:
| GB2200115A | 1988-07-27 | |||
| EP0389898A2 | 1990-10-03 | |||
| EP0449191A1 | 1991-10-02 | |||
| US4749792A | 1988-06-07 | |||
| EP0657415A1 | 1995-06-14 |
Other References:
D. BRILLON ET. AL.: "Silica Gel Catalysed Knoevenagel Condensations of Peptidyl Cyanomethyl Ketones with Aromatic Aldehydes and Ketones.", JOURNAL OF ORGANIC CHEMISTRY., vol. 57, no. 6, 13 March 1992 (1992-03-13), EASTON US, pages 1838 - 42
H. SASAI ET. AL.: "Diastereoselective Catalytic Asymmetric Nitroaldol Reaction Utilising Rare Earth Li-(R)-BINOL Complex. A Highly Efficient Synthesis of Norstatine.", TETRAHEDRON LETTERS., vol. 35, no. 33, 15 August 1994 (1994-08-15), OXFORD GB, pages 6123 - 6
H. SASAI ET. AL.: "Diastereoselective Catalytic Asymmetric Nitroaldol Reaction Utilising Rare Earth Li-(R)-BINOL Complex. A Highly Efficient Synthesis of Norstatine.", TETRAHEDRON LETTERS., vol. 35, no. 33, 15 August 1994 (1994-08-15), OXFORD GB, pages 6123 - 6
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