Title:
AMINO ACID-N-CARBOXY ANHYDRIDES HVAING SUBSTITUENT AT NITROGEN
Document Type and Number:
WIPO Patent Application WO/2002/002538
Kind Code:
A1
Abstract:
Amino acid-N-carboxy anhydrides having an N-acyl substituent at nitrogen which are represented by the following general formula (1); and a process for producing the same. These compounds easily react with free amino acids, alcohols or nucleophilic agents such as anions and serve as useful intermediates in producing amino acid derivatives, optically active compounds, peptides, polypeptides and the like, which are useful in various fields including medicines and pesticides, at a high yield. Moreover, a process for producing diamides by using the compounds of the formula (1) with amine derivatives represented by the following general formula (7). These diamides are also appropriately usable in producing amino acid derivatives, optically active compounds, peptides, polypeptides and the like.
Inventors:
TSUNODA HIDETOSHI (JP)
SEKIGUCHI MICHIRU (JP)
IIZUKA HAJIME (JP)
SAKAI KAZUYA (JP)
SEKIGUCHI MICHIRU (JP)
IIZUKA HAJIME (JP)
SAKAI KAZUYA (JP)
Application Number:
PCT/JP2001/005780
Publication Date:
January 10, 2002
Filing Date:
July 04, 2001
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
TSUNODA HIDETOSHI (JP)
SEKIGUCHI MICHIRU (JP)
IIZUKA HAJIME (JP)
SAKAI KAZUYA (JP)
TSUNODA HIDETOSHI (JP)
SEKIGUCHI MICHIRU (JP)
IIZUKA HAJIME (JP)
SAKAI KAZUYA (JP)
International Classes:
C07C231/10; C07C237/22; C07D263/44; C07D295/185; C07D413/06; C07D413/14; C07D417/06; C07D417/14; C07D471/04; C07D487/08; C07D521/00; (IPC1-7): C07D263/44; C07D413/06; C07D417/06; C07D471/04; C07D471/08
Domestic Patent References:
| WO1989008643A1 | 1989-09-21 |
Foreign References:
| JPS4886886A | 1973-11-15 |
Other References:
CHEMICAL ABSTRACTS, vol. 77, 1972, Columbus, Ohio, US; abstract no. 20166B, XP002947568
WAKSELMAN M. ET AL.: "Urethane protected amino acid N-carboxyanhydrides and fluorides(U-NCAs and U2AAFs)", AMINO ACIDS, vol. 7, no. 1, 1994, pages 67 - 77, XP002947569
See also references of EP 1298127A4
WAKSELMAN M. ET AL.: "Urethane protected amino acid N-carboxyanhydrides and fluorides(U-NCAs and U2AAFs)", AMINO ACIDS, vol. 7, no. 1, 1994, pages 67 - 77, XP002947569
See also references of EP 1298127A4
Attorney, Agent or Firm:
Kaneda, Nobuyuki (16th Kowa Bldg. 9-20 Akasaka 1-chome Minato-ku, Tokyo, JP)
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