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Title:
AMINO ACID PRECURSOR, AMINO ACID, AND PRODUCTION METHOD FOR AMINO ACID, AND PET DIAGNOSTIC TRACER USING AMINO ACID
Document Type and Number:
WIPO Patent Application WO/2015/152128
Kind Code:
A1
Abstract:
Disclosed is an amino acid that can be prevented from being incorporated into normal cells and selectively incorporated into tumor cells, even when used in a PET diagnostic tracer. Also disclosed are an amino acid precursor, a production method for the amino acid, and a PET diagnostic tracer that uses the amino acid. The amino acid of the present invention is represented by formula (II). The amino acid of the present invention is, for example, useful as a PET diagnostic tracer or as a building block for a pharmaceutical intermediate.

Inventors:
YAMAMOTO, Kenichiro (236 Tatsunocho-nakai, Tatsuno-sh, Hyogo 24, 〒6794124, JP)
KODAMA, Kazuya (236 Tatsunocho-nakai, Tatsuno-sh, Hyogo 24, 〒6794124, JP)
SASANO, Yumi (2-3, Murotani 2-chome, Nishi-ku, Kobe-sh, Hyogo 41, 〒6512241, JP)
HUME, William Ewan (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
YASHIO, Keiji (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
NOZAKI, Satoshi (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
Application Number:
JP2015/059862
Publication Date:
October 08, 2015
Filing Date:
March 30, 2015
Export Citation:
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Assignee:
NAGASE & CO., LTD. (1-17, Shinmachi 1-chome Nishi-k, Osaka-shi Osaka 68, 〒5508668, JP)
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 〒3510198, JP)
International Classes:
C07C229/36; A61K51/00; C07B57/00; C07B59/00
Domestic Patent References:
WO2013001088A12013-01-03
Foreign References:
JP2003064046A2003-03-05
FR2378746A11978-08-25
JP2001500850A2001-01-23
JP2009534381A2009-09-24
JP2006516547A2006-07-06
US20110150767A12011-06-23
JP2011505392A2011-02-24
US4925651A1990-05-15
Other References:
WANG L. ET AL.: "Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents", BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 3482 - 3485, XP029213017, ISSN: 0960-894x
JEW S. ET AL.: "Highly Enantioselective Synthesis of a-Alkyl-alanines via the Catalytic Phase-Transfer Alkylation of 2- Naphthyl Aldimine tert-Butyl Ester by Using O(9)- Allyl- N(1)-2',3',4'-trifluorobenzylhydro- cinchonidinium Bromide", J. ORG. CHEM., vol. 68, no. 11, 2003, pages 4514 - 4516, XP055228043, ISSN: 0022-3263
RAJAGOPAL S. ET AL.: "Synthesis of 14C-labeled alpha- methyl tyrosine", APPL. RADIAT. ISOT., vol. 43, no. 8, 1992, pages 979 - 987, XP004135020, DOI: doi:10.1016/0960-894X(96)00060-1
Attorney, Agent or Firm:
SHINDO, Takuya et al. (5th Floor, Okina Bldg. 2-9, Nishitenma 3-chome, Kita-ku, Osaka-sh, Osaka 47, 〒5300047, JP)
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