Title:
AMINO ACID SEQUENCES DIRECTED AGAINST IL18 AND/OR THE IL-18 RECEPTOR AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF DISEASES AND/OR DISORDERS ASSOCIATED WITH IL-18 MEDIATED SIGNALING
Document Type and Number:
WIPO Patent Application WO/2010/040736
Kind Code:
A3
Abstract:
The present invention relates to amino acid sequences that are directed against (as defined herein) IL- 18 and/or the IL- 18 receptor, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as amino acid sequences of the invention compounds of the invention, polypeptides of the invention, respectively).
Inventors:
BLANCHETOT CHRISTOPH (NL)
SZYNOL AGNIESZKA (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
SZYNOL AGNIESZKA (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
Application Number:
PCT/EP2009/062955
Publication Date:
July 15, 2010
Filing Date:
October 06, 2009
Export Citation:
Assignee:
ABLYNX NV (BE)
BLANCHETOT CHRISTOPH (NL)
SZYNOL AGNIESZKA (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
BLANCHETOT CHRISTOPH (NL)
SZYNOL AGNIESZKA (NL)
SAUNDERS MICHAEL JOHN SCOTT (BE)
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
VANLANDSCHOOT PETER (BE)
International Classes:
C07K16/24; C07K16/28
Domestic Patent References:
| WO2007137984A2 | 2007-12-06 | |||
| WO2000056771A1 | 2000-09-28 | |||
| WO1999009063A1 | 1999-02-25 |
Foreign References:
| US20050147610A1 | 2005-07-07 | |||
| EP1621616A1 | 2006-02-01 | |||
| US20020128450A1 | 2002-09-12 |
Other References:
TANIGUCHI M ET AL: "Characterization of anti-human interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 206, no. 1-2, 7 August 1997 (1997-08-07), pages 107 - 113, XP004093123, ISSN: 0022-1759
"Human IL-18 R alpha/IL-1 R5 MAb (Clone 70625)", INTERNET CITATION, XP002454080, Retrieved from the Internet [retrieved on 20071005]
VERMOT-DESROCHES ET AL: "Monoclonal antibodies specific for the IL-18 receptor", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 236, no. 1-2, 1 July 2005 (2005-07-01), pages 101 - 104, XP005197730, ISSN: 0008-8749
"Human IL-18 R alpha/IL-1 R5 MAb (Clone 70625)", INTERNET CITATION, XP002454080, Retrieved from the Internet
VERMOT-DESROCHES ET AL: "Monoclonal antibodies specific for the IL-18 receptor", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 236, no. 1-2, 1 July 2005 (2005-07-01), pages 101 - 104, XP005197730, ISSN: 0008-8749
Attorney, Agent or Firm:
SIEGERT, Georg et al. (Arabellastrasse 4, München, DE)
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