Title:
AMINO ACID TYPE ACYLBORANE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/159628
Kind Code:
A1
Abstract:
An acylborane represented by general formula (1) and a method for producing the acylborane.
(In the formula, each of R1 and R2 independently represents a hydrogen atom, a protecting group, a peptide residue, an alkyl group, an aryl group, an alkoxy group or an acyloxy group; R3 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R4 represents a -B(MIDA) group, -BF3K group or a -B(ORA)(ORB) group (wherein each of RA and RB independently represents a hydrogen atom or the like). In this regard, however, R1 and R3 may combine with each other and form a ring together with a nitrogen atom and a carbon atom, to which R1 and R3 are respectively bonded.)
Inventors:
ITO HAJIME (JP)
TAGUCHI JUMPEI (JP)
IKEDA TOSHIKI (JP)
TAGUCHI JUMPEI (JP)
IKEDA TOSHIKI (JP)
Application Number:
PCT/JP2018/007313
Publication Date:
September 07, 2018
Filing Date:
February 27, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07F5/02
Domestic Patent References:
| WO2003033506A1 | 2003-04-24 |
Other References:
TSENG, CLAIRE C. ET AL.: "Characterization of the Surfactin Synthetase C-Terminal Thioesterase Domain as a Cyclic Depsipeptide Synthase", BIOCHEMISTRY, vol. 41, no. 45, 12 November 2002 (2002-11-12), pages 13350 - 13359, XP002304806
MURAR, CLAUDIA E. ET AL.: "KAHA Ligations That Form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification", J. AM. CHEM. SOC., vol. 136, no. 52, 31 December 2014 (2014-12-31), pages 18140 - 18148, XP055543138, Retrieved from the Internet
MAZUNIN, DMITRY ET AL.: "Potassium Acyltrifluoroborate (KAT) Ligations are Orthogonal to Thiol-Michael and SPAAC Reactions: Covalent Dual Immobilization of Proteins onto Synthetic PEG Hydrogels", HELVETICA CHIMICA ACTA, vol. 100, no. 2, 16 December 2016 (2016-12-16), pages 1 - 10, XP055543171, Retrieved from the Internet
TAGUCHI, JUMPEI. ET AL.: "Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate", ANGEWANDTE CHEMIE, vol. 56, no. 44, 14 September 2017 (2017-09-14), pages 13847 - 13851, XP055543181, Retrieved from the Internet
MURAR, CLAUDIA E. ET AL.: "KAHA Ligations That Form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification", J. AM. CHEM. SOC., vol. 136, no. 52, 31 December 2014 (2014-12-31), pages 18140 - 18148, XP055543138, Retrieved from the Internet
MAZUNIN, DMITRY ET AL.: "Potassium Acyltrifluoroborate (KAT) Ligations are Orthogonal to Thiol-Michael and SPAAC Reactions: Covalent Dual Immobilization of Proteins onto Synthetic PEG Hydrogels", HELVETICA CHIMICA ACTA, vol. 100, no. 2, 16 December 2016 (2016-12-16), pages 1 - 10, XP055543171, Retrieved from the Internet
TAGUCHI, JUMPEI. ET AL.: "Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate", ANGEWANDTE CHEMIE, vol. 56, no. 44, 14 September 2017 (2017-09-14), pages 13847 - 13851, XP055543181, Retrieved from the Internet
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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