Title:
AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA-PROTEIN
Document Type and Number:
WIPO Patent Application WO2003082807
Kind Code:
A3
Abstract:
This invention relates to certain beta-amino acids that bind to the alpha-2-delta (alpha2delta) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
Inventors:
BARTA NANCY SUE (US)
SCHWARZ JACOB BRADLEY (US)
THORPE ANDREW JOHN (US)
WUSTROW DAVID JUERGEN (US)
SCHWARZ JACOB BRADLEY (US)
THORPE ANDREW JOHN (US)
WUSTROW DAVID JUERGEN (US)
Application Number:
PCT/IB2003/000976
Publication Date:
December 24, 2003
Filing Date:
March 17, 2003
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
BARTA NANCY SUE (US)
SCHWARZ JACOB BRADLEY (US)
THORPE ANDREW JOHN (US)
WUSTROW DAVID JUERGEN (US)
BARTA NANCY SUE (US)
SCHWARZ JACOB BRADLEY (US)
THORPE ANDREW JOHN (US)
WUSTROW DAVID JUERGEN (US)
International Classes:
A61K31/195; A61K31/197; A61K31/198; A61P1/00; A61P1/12; A61P1/04; A61P1/14; A61P3/10; A61P5/24; A61P7/10; A61P9/00; A61P15/00; A61P17/06; A61P19/02; A61P21/00; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P27/16; A61P29/00; C07C229/08; C07C229/28; C07C229/34; (IPC1-7): C07C229/08; C07C229/28; A61K31/195; A61P25/00; A61P1/00
Domestic Patent References:
| WO1998040055A2 | 1998-09-17 | |||
| WO2000076958A2 | 2000-12-21 | |||
| WO1998017627A1 | 1998-04-30 | |||
| WO2001088101A2 | 2001-11-22 |
Foreign References:
| FR1377736A | 1964-11-06 |
Other References:
WILLIAM H. GERWICK ET AL.: "Total structure of hormothamnin A,...", TETRAHEDRON., vol. 48, no. 12, 1992, OXFORD GB, pages 2313 - 2324, XP002242302
CHARLES W. JEFFORD ET AL.: "An enantiospecific synthesis of beta-amino acids", TETRAHEDRON LETTERS., vol. 34, no. 7, 1993, OXFORD GB, pages 1111 - 1114, XP002242303
CHEMICAL ABSTRACTS, vol. 52, no. 15, 1958, Columbus, Ohio, US; abstract no. 12838f, YA. L. GOL'DFARB ET AL.: "Synthesis of aliphatic amino acids from thiophene derivatives." page 12837; column 2; XP002242304
CHEMICAL ABSTRACTS, vol. 45, no. 19, 1951, Columbus, Ohio, US; abstract no. 8453b, V. M. RODIONOV ET AL.: "The Hoffmann reaction..." page 8453; column 1; XP002242305
CHEMICAL ABSTRACTS, vol. 49, no. 18, 1955, Columbus, Ohio, US; abstract no. 12291d, G. M. BORODINA ET AL.: "Synthesis of some derivatives of aliphatic beta-amino acids." page 12291; column 1; XP002242306
CHEMICAL ABSTRACTS, vol. 50, no. 20, 1956, Columbus, Ohio, US; abstract no. 14523i, V. M. RODIONOV ET AL.: "Synthesis and separation of diastereoisomeric gamma-ethyl-beta-aminocaprylic acids and their derivatives." page 14523; column 1; XP002242307
CHEMICAL ABSTRACTS, vol. 96, no. 13, 1982, Columbus, Ohio, US; abstract no. 104715k, SLOPIANKA, MARION ET AL.: "Thiocarbonyl olefination." page 757; column 2; XP002242308
CHEMICAL ABSTRACTS, vol. 105, no. 21, 1986, Columbus, Ohio, US; abstract no. 186897n, GRIFFITH OWEN W. ET AL.: "Liquid chromatographic separation of enantiomers of beta-amino acids using a chiral stationary phase." page 357; column 1; XP002242309
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242310
DATABASE CROSSFIRE BEILSTEIN BEISTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242311
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242312
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242313
CHARLES W. JEFFORD ET AL.: "An enantiospecific synthesis of beta-amino acids", TETRAHEDRON LETTERS., vol. 34, no. 7, 1993, OXFORD GB, pages 1111 - 1114, XP002242303
CHEMICAL ABSTRACTS, vol. 52, no. 15, 1958, Columbus, Ohio, US; abstract no. 12838f, YA. L. GOL'DFARB ET AL.: "Synthesis of aliphatic amino acids from thiophene derivatives." page 12837; column 2; XP002242304
CHEMICAL ABSTRACTS, vol. 45, no. 19, 1951, Columbus, Ohio, US; abstract no. 8453b, V. M. RODIONOV ET AL.: "The Hoffmann reaction..." page 8453; column 1; XP002242305
CHEMICAL ABSTRACTS, vol. 49, no. 18, 1955, Columbus, Ohio, US; abstract no. 12291d, G. M. BORODINA ET AL.: "Synthesis of some derivatives of aliphatic beta-amino acids." page 12291; column 1; XP002242306
CHEMICAL ABSTRACTS, vol. 50, no. 20, 1956, Columbus, Ohio, US; abstract no. 14523i, V. M. RODIONOV ET AL.: "Synthesis and separation of diastereoisomeric gamma-ethyl-beta-aminocaprylic acids and their derivatives." page 14523; column 1; XP002242307
CHEMICAL ABSTRACTS, vol. 96, no. 13, 1982, Columbus, Ohio, US; abstract no. 104715k, SLOPIANKA, MARION ET AL.: "Thiocarbonyl olefination." page 757; column 2; XP002242308
CHEMICAL ABSTRACTS, vol. 105, no. 21, 1986, Columbus, Ohio, US; abstract no. 186897n, GRIFFITH OWEN W. ET AL.: "Liquid chromatographic separation of enantiomers of beta-amino acids using a chiral stationary phase." page 357; column 1; XP002242309
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242310
DATABASE CROSSFIRE BEILSTEIN BEISTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242311
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242312
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002242313
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