Title:
AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005070871
Kind Code:
A3
Abstract:
The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
Inventors:
HEROLD PETER (CH)
STUTZ STEFAN (CH)
STOJANOVIC ALEKSANDAR (CH)
TSCHINKE VINCENZO (CH)
MARTI CHRISTIANE (CH)
QUIRMBACH MICHAEL (CH)
STUTZ STEFAN (CH)
STOJANOVIC ALEKSANDAR (CH)
TSCHINKE VINCENZO (CH)
MARTI CHRISTIANE (CH)
QUIRMBACH MICHAEL (CH)
Application Number:
PCT/EP2005/050274
Publication Date:
September 22, 2005
Filing Date:
January 21, 2005
Export Citation:
Assignee:
SPEEDEL EXPERIMENTA AG (CH)
HEROLD PETER (CH)
STUTZ STEFAN (CH)
STOJANOVIC ALEKSANDAR (CH)
TSCHINKE VINCENZO (CH)
MARTI CHRISTIANE (CH)
QUIRMBACH MICHAEL (CH)
HEROLD PETER (CH)
STUTZ STEFAN (CH)
STOJANOVIC ALEKSANDAR (CH)
TSCHINKE VINCENZO (CH)
MARTI CHRISTIANE (CH)
QUIRMBACH MICHAEL (CH)
International Classes:
C07C213/08; C07C235/60; C07C237/06; C07C237/10; C07C237/22; C07C237/24; C07C243/28; C07C275/14; C07C311/05; C07C311/10; C07C311/13; C07C311/14; C07C311/18; C07D211/76; C07D295/13; C07D311/00; C07D471/10; C07C215/06; C07C215/20; (IPC1-7): C07C213/08; C07C215/06; C07C215/20; A61K31/165
Domestic Patent References:
| WO2002040007A1 | 2002-05-23 |
Foreign References:
| EP0519433A1 | 1992-12-23 |
Other References:
RADDATZ P ET AL: "RENIN INHIBITORS CONTAINING NEW P1-P1' DIPEPTIDE MIMETICS WITH HETEROCYCLES IN P1'", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 19, 18 September 1992 (1992-09-18), pages 3525 - 3536, XP002050635, ISSN: 0022-2623
ALLIKMETS K: "ALISKIREN SPEEDEL", CURRENT OPINION IN INVESTIGATIONAL DRUGS, PHARMAPRESS, US, vol. 3, no. 10, 2002, pages 1479 - 1482, XP009017210, ISSN: 1472-4472
WOOD J M ET AL: "Structure-based design of aliskiren, a novel orally effective renin inhibitor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 308, no. 4, 5 September 2003 (2003-09-05), pages 698 - 705, XP004447169, ISSN: 0006-291X
ALLIKMETS K: "ALISKIREN SPEEDEL", CURRENT OPINION IN INVESTIGATIONAL DRUGS, PHARMAPRESS, US, vol. 3, no. 10, 2002, pages 1479 - 1482, XP009017210, ISSN: 1472-4472
WOOD J M ET AL: "Structure-based design of aliskiren, a novel orally effective renin inhibitor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 308, no. 4, 5 September 2003 (2003-09-05), pages 698 - 705, XP004447169, ISSN: 0006-291X
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