Title:
AMINO-COMBRETASTATIN DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/100487
Kind Code:
A1
Abstract:
Disclosed is an amino-combretastatin derivative, and in particular a compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a hydrate of the pharmaceutically acceptable salt thereof, a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof, and an isomer thereof. In general formula (I), R1 is selected from a C1-C3 alkyl or a C1-C3 haloalkyl, and R2 and R3 are respectively and independently selected from a C1-C6 alkyl, a C1-C6 haloalkyl or a C1-C6 alcohol group. The present invention also relates to the use of such compounds in the preparation of drugs for the treatment of diseases caused by abnormal neovascularization, and tubulin aggregation inhibitors.
Inventors:
WANG JIANPING (CN)
Application Number:
PCT/CN2021/128275
Publication Date:
May 19, 2022
Filing Date:
November 02, 2021
Export Citation:
Assignee:
YIWUHUAYAO PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
A61K31/167; C07C237/08; A61K31/661; A61P35/00; A61P35/02; C07C41/22; C07C43/225; C07C201/12; C07C205/37; C07C213/02; C07C217/02; C07C231/02; C07C231/12; C07C233/25; C07F9/54
Domestic Patent References:
| WO2016067311A1 | 2016-05-06 |
Foreign References:
| EP2942345A1 | 2015-11-11 | |||
| CN103012248A | 2013-04-03 | |||
| CN107382796A | 2017-11-24 | |||
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| CN101085743A | 2007-12-12 | |||
| CN103539642A | 2014-01-29 | |||
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| CN101220054A | 2008-07-16 | |||
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| CN101074189A | 2007-11-21 |
Attorney, Agent or Firm:
IPROPERTYONE INTELLECTUAL PROPERTY CO., LTD. (CN)
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