AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN

Title:

AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN

Document Type and Number:

WIPO Patent Application WO2003099284

Kind Code:

B1

Abstract:

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

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Inventors:

DOHERTY ELIZABETH M (US)
ZHU JIAWANG (US)
STEC MARKIAN (US)
NORMAN MARK H (US)
FOTSCH CHRISTOPHER H (US)
CHEN NING (US)
CHAKRABARTI PARTHA P (US)
OGNYANOV VASSIL I (US)
PETTUS LIPING H (US)
WANG HUI-LING (US)
WANG XIANGHONG (US)
ARASASINGHAM PREMILLA (US)

Application Number:

PCT/US2003/016655

Publication Date:

April 01, 2004

Filing Date:

May 20, 2003

Export Citation:

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Assignee:

AMGEN INC (US)
DOHERTY ELIZABETH M (US)
ZHU JIAWANG (US)
STEC MARKIAN (US)
NORMAN MARK H (US)
FOTSCH CHRISTOPHER H (US)
CHEN NING (US)
CHAKRABARTI PARTHA P (US)
OGNYANOV VASSIL I (US)
PETTUS LIPING H (US)
WANG HUI-LING (US)
WANG XIANGHONG (US)
ARASASINGHAM PREMILLA (US)

International Classes:

A61K31/4709; A61K31/501; A61K31/505; A61K31/506; A61K31/5377; A61P1/00; A61P1/04; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P27/02; A61P29/00; A61P37/08; C07D209/08; C07D209/12; C07D209/42; C07D209/48; C07D213/26; C07D213/643; C07D213/74; C07D213/75; C07D215/227; C07D215/38; C07D217/04; C07D231/40; C07D231/56; C07D233/38; C07D237/20; C07D239/42; C07D239/90; C07D241/42; C07D263/56; C07D265/36; C07D277/62; C07D277/82; C07D307/79; C07D319/20; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D407/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D213/64; C07D215/22; (IPC1-7): A61K31/501; A61K31/506; A61P25/00; C07D417/12; C07D405/12; C07D403/12; C07D401/12; C07D239/42; C07D471/04; C07D417/14

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