Title:
AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/019204
Kind Code:
A1
Abstract:
An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.
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Inventors:
WANG YIHAN (CN)
REN XINGYE (CN)
JIN JIAN (CN)
LI HUANYIN (CN)
AI YIXIN (CN)
REN XINGYE (CN)
JIN JIAN (CN)
LI HUANYIN (CN)
AI YIXIN (CN)
Application Number:
PCT/CN2017/094102
Publication Date:
February 01, 2018
Filing Date:
July 24, 2017
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D403/04; A61K31/506; A61P35/00; A61P35/02; C07D471/04
Domestic Patent References:
WO2016173438A1 | 2016-11-03 | |||
WO2015127872A1 | 2015-09-03 | |||
WO2015170266A1 | 2015-11-12 | |||
WO2004074262A1 | 2004-09-02 | |||
WO2016054987A1 | 2016-04-14 | |||
WO2010138578A1 | 2010-12-02 | |||
WO2015195228A1 | 2015-12-23 | |||
WO2009158571A1 | 2009-12-30 | |||
WO2016022460A1 | 2016-02-11 |
Foreign References:
CN106749193A | 2017-05-31 | |||
CN106831730A | 2017-06-13 | |||
CN106749267A | 2017-05-31 | |||
CN105085489A | 2015-11-25 | |||
CN104803925A | 2015-07-29 |
Other References:
See also references of EP 3492462A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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