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Title:
AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/019204
Kind Code:
A1
Abstract:
An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.

Inventors:
WANG YIHAN (CN)
REN XINGYE (CN)
JIN JIAN (CN)
LI HUANYIN (CN)
AI YIXIN (CN)
Application Number:
PCT/CN2017/094102
Publication Date:
February 01, 2018
Filing Date:
July 24, 2017
Export Citation:
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Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D403/04; A61K31/506; A61P35/00; A61P35/02; C07D471/04
Domestic Patent References:
WO2016173438A12016-11-03
WO2015127872A12015-09-03
WO2015170266A12015-11-12
WO2004074262A12004-09-02
WO2016054987A12016-04-14
WO2010138578A12010-12-02
WO2015195228A12015-12-23
WO2009158571A12009-12-30
WO2016022460A12016-02-11
Foreign References:
CN106749193A2017-05-31
CN106831730A2017-06-13
CN106749267A2017-05-31
CN105085489A2015-11-25
CN104803925A2015-07-29
Other References:
See also references of EP 3492462A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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