Title:
AMINO-SUBSTITUTED INDOLIZINE COMPOUND HAVING ANTICANCER ACTIVITY AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/232663
Kind Code:
A1
Abstract:
Provided are an amino-substituted indolizine compound having anticancer activity and a derivative thereof. Said compound and derivative thereof as shown in formula (I) have an inhibitory effect on a plurality of cancers and tumors.
Inventors:
CAO HUA (CN)
GUO PENGFENG (CN)
GUO PENGFENG (CN)
Application Number:
PCT/CN2018/000244
Publication Date:
December 12, 2019
Filing Date:
July 04, 2018
Export Citation:
Assignee:
GUANG DONG PHARMACEUTICAL UNIV (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00
Domestic Patent References:
| WO2010027762A1 | 2010-03-11 |
Foreign References:
| CN1649867A | 2005-08-03 | |||
| US20060199962A1 | 2006-09-07 | |||
| CN103641827A | 2014-03-19 |
Other References:
JUNG, YOUNGEUN ET AL.: "C3 Functionalization of Indolizines via In (III)-Catalyzed Three- Component Reaction", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, no. 45, 10 September 2015 (2015-09-10), pages 10986 - 10994, XP055667256, ISSN: 1477-0520
YANG, DAJI ET AL.: "One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal- Free, Three-Component Reaction of 2-(Pyridin-2-yl) Acetates, Ynals, and Alcohols or Thiols", ORGANIC LETTERS, vol. 20, no. 8, 3 April 2018 (2018-04-03), pages 2477 - 2480, XP055667260, ISSN: 1523-7060
YANG, DAJI ET AL.: "One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal- Free, Three-Component Reaction of 2-(Pyridin-2-yl) Acetates, Ynals, and Alcohols or Thiols", ORGANIC LETTERS, vol. 20, no. 8, 3 April 2018 (2018-04-03), pages 2477 - 2480, XP055667260, ISSN: 1523-7060
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