Title:
AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS
Document Type and Number:
WIPO Patent Application WO2001034617
Kind Code:
A3
Abstract:
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
Inventors:
JOHNSON DAVID A (US)
SOWELL C GREGORY (US)
SOWELL C GREGORY (US)
Application Number:
PCT/US2000/031340
Publication Date:
November 08, 2001
Filing Date:
November 13, 2000
Export Citation:
Assignee:
CORIXA CORP (US)
JOHNSON DAVID A (US)
SOWELL C GREGORY (US)
JOHNSON DAVID A (US)
SOWELL C GREGORY (US)
International Classes:
A61K9/127; A61K31/7028; A61K39/00; A61K39/39; A61K47/02; A61K47/06; A61K47/10; A61K47/18; A61K47/22; A61K47/24; A61K47/26; A61K47/34; A61P37/04; A61P43/00; C07H13/06; C07H15/04; C07H15/14; (IPC1-7): C07H13/06; C07H15/04; A61K31/7028; A61K39/39; A61P37/02
Domestic Patent References:
| WO1998050399A1 | 1998-11-12 |
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