AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY

WIPO Patent Application WO2003089449

A3

The invention relates to sterol derivatives of formula (I) and to a method for the production of said compounds, a medicament using one of said compounds and a pharmaceutical composition comprising said medicament.

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POIROT MARC (FR)
DE MEDINA PHILIPPE (FR)
POIROT SANDRINE (FR)

PCT/FR2003/001248

April 01, 2004

April 18, 2003

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INST NAT SANTE RECH MED (FR)
POIROT MARC (FR)
DE MEDINA PHILIPPE (FR)
POIROT SANDRINE (FR)

A61K31/575; A61K31/58; A61P25/00; A61P25/16; A61P25/28; A61P35/00; A61P37/04; C07J41/00; C07J43/00; (IPC1-7): C07J43/00; C07J41/00; A61K31/575; A61P35/00

SHAFIULLAH ET AL: "SYNTHESES OF STEROIDAL SUBSTITUTED TETRAZOLES", ACTA CHIMICA HUNGARICA, vol. 127, no. 3, 1990, pages 391 - 394, XP008010474, ISSN: 0231-3146
EL KIHEL, L. ET AL: "Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)", ANTICANCER RESEARCH (1999), 19(2A), 1229-1234, XP008010475
SUH N ET AL: "A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9- dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.", CANCER RESEARCH. UNITED STATES 15 JAN 1999, vol. 59, no. 2, 15 January 1999 (1999-01-15), pages 336 - 341, XP002220453, ISSN: 0008-5472

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