Title:
AMINOALKYL SUBSTITUTED CHALCONES AND ANALOGUES AND DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/151789
Kind Code:
A3
Abstract:
This invention relates to B-ring aminoalkyl substituted chalcones and analogues thereof. It also relates to processes for the synthesis of such compounds and to the use of such compounds as medicaments, in particular but not exclusively for the treatment of cancer and malaria.
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Inventors:
VAN DER WESTHUIZEN JAN HENDRIK (ZA)
ELJALEEL ANWAR ELBUSHRA MOHAMMED NOR (SD)
BONNET SUSANNA LUCIA (ZA)
WILHELM-MOUTON ANKE (ZA)
ELJALEEL ANWAR ELBUSHRA MOHAMMED NOR (SD)
BONNET SUSANNA LUCIA (ZA)
WILHELM-MOUTON ANKE (ZA)
Application Number:
PCT/IB2011/052396
Publication Date:
May 24, 2012
Filing Date:
May 31, 2011
Export Citation:
Assignee:
UNIV FREE STATE ZA (ZA)
VAN DER WESTHUIZEN JAN HENDRIK (ZA)
ELJALEEL ANWAR ELBUSHRA MOHAMMED NOR (SD)
BONNET SUSANNA LUCIA (ZA)
WILHELM-MOUTON ANKE (ZA)
VAN DER WESTHUIZEN JAN HENDRIK (ZA)
ELJALEEL ANWAR ELBUSHRA MOHAMMED NOR (SD)
BONNET SUSANNA LUCIA (ZA)
WILHELM-MOUTON ANKE (ZA)
International Classes:
C07C225/22
Other References:
SIMON F. NIELSEN ET.AL.: "Cationic chalcone antibiotics. Design, synthesis, and mechanism of action", J. MED. CHEM., vol. 48, 2005, pages 2667 - 2677, XP002664898
MICHAEL J. HALL ET AL: "A Modular Synthesis of Unsymmetrical Tetraarylazadipyrromethenes", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 70, no. 14, 1 July 2005 (2005-07-01), pages 5571 - 5578, XP055013649, ISSN: 0022-3263, DOI: 10.1021/jo050696k
JONATHAN R. DIMMOCK ET AL: "Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 7, 1 March 1998 (1998-03-01), pages 1014 - 1026, XP055013705, ISSN: 0022-2623, DOI: 10.1021/jm970432t
SOON SUNG LIM ET.AL.: "In vitro antimalaian activity of flavonoids and chalcones", BULL. KOREAN CHEM. SOC., vol. 28, no. 12, 2007, pages 2495 - 2497, XP002664899
JULIUS V. BRAUN ET.AL.: "Die realtive Festigkeit cyclischer Basen, VII: Substituierte Tetrahydrochilolin Ringe", CHEMISCHE BERICHTE, 1922, pages 3803 - 3817, XP002671586
J. V. BRAUN ET.AL.: "Synthesen in der fettaromatische Reihe X: Derivate der Diarylparaffine", CHEMISCHE BERICHTE, 1913, pages 1511 - 1526, XP002671587
MICHAEL J. HALL ET AL: "A Modular Synthesis of Unsymmetrical Tetraarylazadipyrromethenes", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 70, no. 14, 1 July 2005 (2005-07-01), pages 5571 - 5578, XP055013649, ISSN: 0022-3263, DOI: 10.1021/jo050696k
JONATHAN R. DIMMOCK ET AL: "Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 7, 1 March 1998 (1998-03-01), pages 1014 - 1026, XP055013705, ISSN: 0022-2623, DOI: 10.1021/jm970432t
SOON SUNG LIM ET.AL.: "In vitro antimalaian activity of flavonoids and chalcones", BULL. KOREAN CHEM. SOC., vol. 28, no. 12, 2007, pages 2495 - 2497, XP002664899
JULIUS V. BRAUN ET.AL.: "Die realtive Festigkeit cyclischer Basen, VII: Substituierte Tetrahydrochilolin Ringe", CHEMISCHE BERICHTE, 1922, pages 3803 - 3817, XP002671586
J. V. BRAUN ET.AL.: "Synthesen in der fettaromatische Reihe X: Derivate der Diarylparaffine", CHEMISCHE BERICHTE, 1913, pages 1511 - 1526, XP002671587
Attorney, Agent or Firm:
DM KISCH INC. (2146 Sandton, ZA)
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