Title:
AMINOALKYLCYCLOPROPANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/022521
Kind Code:
A1
Abstract:
An optically active compound represented by general formula (1), a racemate thereof, and a pharmaceutically acceptable acid-addition salt thereof, wherein R represents either a C1-C5 (un)saturated linear or branched aliphatic group, or a phenyl group which may be substituted by one to three substituents selected independently from the group consisting of halogen, C1-C4 alkyl, nitro, amino, hydroxy and C1-C4 alkoxy; and the asterisk represents an asymmetric carbon atom. These compounds have a remarkably high NMDA receptor antagonism as compared with the conventional aminomethylcyclopropane derivatives and are useful as a cerebral infarction preventive and an ischemic disease protective.
Inventors:
MOCHIZUKI DAISUKE (JP)
SHUTO SATOSHI (JP)
SHUTO SATOSHI (JP)
Application Number:
PCT/JP1995/000254
Publication Date:
August 24, 1995
Filing Date:
February 22, 1995
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
MATSUDA AKIRA (JP)
MOCHIZUKI DAISUKE (JP)
SHUTO SATOSHI (JP)
MATSUDA AKIRA (JP)
MOCHIZUKI DAISUKE (JP)
SHUTO SATOSHI (JP)
International Classes:
C07B57/00; C07C237/24; (IPC1-7): C07C237/24; A61K31/165
Foreign References:
| JPH0356415A | 1991-03-12 | |||
| JPS61251650A | 1986-11-08 | |||
| JPS584752A | 1983-01-11 |
Other References:
See also references of EP 0747348A4
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