Title:
AMINOBORANE ACID DERIVATIVE AND PROTEASOME INHIBITORY DRUG CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2003/033506
Kind Code:
A1
Abstract:
A novel aminoborane acid derivative represented by the general formula (1): (1) (wherein X is a group of the general formula (2), (3), or (4)&semi (2) (3) (4) Y is the group of the formula (5) or (6)&semi (5) (6) R1 and R2 are the same or different and each is C3−6 alkyl or C1−6 alkyl substituted by phenyl&semi Z1 is oxygen or sulfur&semi Z2 is hydrogen, methoxy, or halogeno&semi and m is 1 or 2), which has proteasome inhibitory activity. The compound having proteasome inhibitory activity is useful as an immunosuppressant, anti−inflammatory agent, antiallergic, remedy for autoimmune diseases, remedy for chronic inflammatory diseases such as inflammatory bowel diseases (ulcerative colitis and Crohn's disease), anticancer agent, or remedy for nerve degeneration diseases.
Inventors:
SATOH HIROAKI (JP)
UENO MASAHIRO (JP)
TACHIBANA YOJI (JP)
NAKAMARU KOICHI (JP)
KOJIMA RYOTARO (JP)
UENO MASAHIRO (JP)
TACHIBANA YOJI (JP)
NAKAMARU KOICHI (JP)
KOJIMA RYOTARO (JP)
Application Number:
PCT/JP2002/010450
Publication Date:
April 24, 2003
Filing Date:
October 08, 2002
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
NISSHIN PHARMA INC (JP)
SATOH HIROAKI (JP)
UENO MASAHIRO (JP)
TACHIBANA YOJI (JP)
NAKAMARU KOICHI (JP)
KOJIMA RYOTARO (JP)
NISSHIN PHARMA INC (JP)
SATOH HIROAKI (JP)
UENO MASAHIRO (JP)
TACHIBANA YOJI (JP)
NAKAMARU KOICHI (JP)
KOJIMA RYOTARO (JP)
International Classes:
A61K31/69; A61P1/04; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07F5/02; (IPC1-7): C07F5/02; A61K31/69; A61P1/04; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00
Foreign References:
| US6083903A | 2000-07-04 |
Attorney, Agent or Firm:
Takagi, Chiyoshi (10 Kojimachi 1-chom, Chiyoda-ku Tokyo, JP)
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