Β-AMINOCARBONYL COMPOUND PRODUCTION METHOD

Title:

Β-AMINOCARBONYL COMPOUND PRODUCTION METHOD

Document Type and Number:

WIPO Patent Application WO/2012/002203

Kind Code:

A1

Abstract:

Disclosed is a production method for obtaining an optically active β-aminocarbonyl compound by a Mannich reaction of an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and 1-2 times in moles, relative to said BINOL, of dialkylmagnesium (two alkyl groups that are the same or different).

Inventors:

ISHIHARA KAZUAKI (JP)
HATANO MANABU (JP)
HORIBE TAKAHIRO (JP)

Application Number:

PCT/JP2011/064220

Publication Date:

January 05, 2012

Filing Date:

June 22, 2011

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Assignee:

UNIV NAGOYA NAT UNIV CORP (JP)
ISHIHARA KAZUAKI (JP)
HATANO MANABU (JP)
HORIBE TAKAHIRO (JP)

International Classes:

C07C227/10; C07C229/24; C07C269/06; C07C271/22; C07D213/55; C07D307/54; C07D333/24; C07B53/00; C07B61/00

Foreign References:

JP2008163022A	2008-07-17
JP2010207786A	2010-09-24

Other References:

CHEMISTRY- AN ASIAN JOURNAL, vol. 5, no. 3, 2010, pages 493 - 495, XP055069388
CHEM. EUR. J., vol. 9, 2003, pages 2359
CHEM. COMMUN., 2006, pages L191
J. AM. CHEM. SOC., vol. 128, 2006, pages 6048
J. AM. CHEM. SOC., vol. 130, 2008, pages 2170
J. ORG. CHEM., vol. 75, 2010, pages 963
SYNTHESIS, 2010, pages L860
EUR. J. ORG. CHEM., 2008, pages 2248
SYNLETT., 2001, pages 1461
See also references of EP 2657222A4

Attorney, Agent or Firm:

ITEC INTERNATIONAL PATENT FIRM (JP)
Patent business corporation Itec international patent firm (JP)

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