Title:
AMINOGLYCOSIDE STEROIDS, A PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO1987004167
Kind Code:
A2
Abstract:
Compounds of formula (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta ) and their pharmaceutically acceptable salts are useful as antihypertensive agents. Their preparation and use as well as pharmaceutical compositions containing them are also described.
Inventors:
CHIODINI LAURA (IT)
GOBBINI MAURO (IT)
MANTEGANI SERGIO (IT)
RUGGIERI DANIELA (IT)
TEMPERILLI ALDEMIO (IT)
TRAQUANDI GABRIELLA (IT)
FERRARI PATRIZIA (IT)
GOBBINI MAURO (IT)
MANTEGANI SERGIO (IT)
RUGGIERI DANIELA (IT)
TEMPERILLI ALDEMIO (IT)
TRAQUANDI GABRIELLA (IT)
FERRARI PATRIZIA (IT)
Application Number:
PCT/EP1987/000004
Publication Date:
July 16, 1987
Filing Date:
January 07, 1987
Export Citation:
Assignee:
ERBA FARMITALIA (IT)
International Classes:
C07J1/00; A61K31/58; C07J71/00
Other References:
CHEMICAL ABSTRACTS, Vol. 102, No. 21, 27 May 1985 (Columbus, Ohio, USA), I.F. MAKEREVICH et al., "Side Reactions During Saponification of Acyl Cardenolides with Ammonia", see page 607, Abstract No. 185349m, Khim. Prir. Soedin. 1984, (3), 394-5
Helvetica Chimica Acta, Vol. 55, No. 5, 1972 (Basel, CH), A.F. KRASSO et al., "Zur Stereochemie der Epoxycardanolide (Isogenine)", pages 1352-1371, see pages 1354; 1364-1371
Journal of the Chemical Society, Chemical Communications, 1967 (London, GB), T.R. KASTURI et al., "Synthesis of Isobufalin Methyl Ester", see pages 644-646
CHEMICAL ABSTRACTS, Vol. 78, Nr. 19, 14 May 1973 (Columbus, Ohio, USA), J.N. DAVISSON et al., "Inhibition and Potentiation of Ouabain Inotropism by Modified Cardenolides", see page 16, Abstract No. 119146c, Proc. West. Pharmacol. Soc. 1972, 15, 31-4
Helvetica Chimica Acta, Vol. 55, No. 5, 1972 (Basel, CH), A.F. KRASSO et al., "Zur Stereochemie der Epoxycardanolide (Isogenine)", pages 1352-1371, see pages 1354; 1364-1371
Journal of the Chemical Society, Chemical Communications, 1967 (London, GB), T.R. KASTURI et al., "Synthesis of Isobufalin Methyl Ester", see pages 644-646
CHEMICAL ABSTRACTS, Vol. 78, Nr. 19, 14 May 1973 (Columbus, Ohio, USA), J.N. DAVISSON et al., "Inhibition and Potentiation of Ouabain Inotropism by Modified Cardenolides", see page 16, Abstract No. 119146c, Proc. West. Pharmacol. Soc. 1972, 15, 31-4
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