Title:
AMINOHETEROARYL COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/148331
Kind Code:
A1
Abstract:
Provided herein are novel compounds (e.g., Formula I, II, III, or IV), pharmaceutical compositions, and methods of using the same. The compounds herein can typically induce UCP-1 expression and/or browning of white adipose tissues. The compounds herein can also be used for treating a variety of diseases or disorders, such as a metabolic disease or disorder such as obesity and/or diabetes (e.g., Type 2 diabetes) and/or a liver disease or disorder such as NASH and/or non-alcoholic fatty liver disease.
Inventors:
CHENG WEI (CN)
WU DONGHAI (CN)
WU DONGHAI (CN)
Application Number:
PCT/CN2022/070011
Publication Date:
July 14, 2022
Filing Date:
January 04, 2022
Export Citation:
Assignee:
BEIJING ERAI THERAPEUTICS CO LTD (CN)
International Classes:
A61K31/426; A61K31/427; A61P3/00; A61P3/04; A61P3/10; C07D277/40; C07D417/12
Domestic Patent References:
| WO2005066180A1 | 2005-07-21 | |||
| WO2007006714A1 | 2007-01-18 | |||
| WO2019222497A1 | 2019-11-21 | |||
| WO2005000298A2 | 2005-01-06 | |||
| WO2006028970A1 | 2006-03-16 |
Foreign References:
| US20180037556A1 | 2018-02-08 | |||
| US20090247526A1 | 2009-10-01 |
Other References:
MATHEW BINI; RUIZ PEDRO; DUTTA SHILPA; ENTREKIN JORDAN T.; ZHANG SIXUE; PATEL KAVAL D.; SIMMONS MICAH S.; AUGELLI-SZAFRAN CORINNE : "Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 210, 22 October 2020 (2020-10-22), AMSTERDAM, NL , pages 1 - 20, XP086432049, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112952
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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