Title:
AMINOPHENOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1996/028416
Kind Code:
A1
Abstract:
Aminophenol derivatives represented by general formula (1), salts thereof or optical isomers thereof, and a gastrin receptor antagonist, a cholecystokinin receptor antagonist and a remedy for digestive tract diseases containing the same, wherein X represents O or S; A represents alkylene; R1 represents phenyl, etc.; R2 and R3 represent each H or alkyl; R4 represents substituted carbamoylalkyl, etc.; and R5 represents substituted amino, etc. The compounds have a potent gastrin or CCK-A receptor antagonism and a high selectivity for one of the CCK-A and gastrin receptor and are useful as a preventive or remedy particularly for digestive tract diseases such as peptic ulcer or a remedy for central nervous diseases.
Inventors:
YOKOHAMA SHUICHI (JP)
KAWAGOE KEIICHI (JP)
TAKEDA YASUYUKI (JP)
YOKOMIZO YOSHIHIRO (JP)
YOKOMIZO AKI (JP)
KAWAGOE KEIICHI (JP)
TAKEDA YASUYUKI (JP)
YOKOMIZO YOSHIHIRO (JP)
YOKOMIZO AKI (JP)
Application Number:
PCT/JP1996/000611
Publication Date:
September 19, 1996
Filing Date:
March 12, 1996
Export Citation:
Assignee:
DAIICHI SEIYAKU CO (JP)
YOKOHAMA SHUICHI (JP)
KAWAGOE KEIICHI (JP)
TAKEDA YASUYUKI (JP)
YOKOMIZO YOSHIHIRO (JP)
YOKOMIZO AKI (JP)
YOKOHAMA SHUICHI (JP)
KAWAGOE KEIICHI (JP)
TAKEDA YASUYUKI (JP)
YOKOMIZO YOSHIHIRO (JP)
YOKOMIZO AKI (JP)
International Classes:
C07C275/16; C07C275/28; (IPC1-7): C07C275/28; C07C309/19; C07D209/08; C07D215/08; C07D207/04; C07D295/18; C07D221/20; A61K31/17; A61K31/185; A61K31/40; A61K31/47; A61K31/445
Foreign References:
| JPH05506643A | 1993-09-30 |
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