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Title:
AMINOPYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/062194
Kind Code:
A1
Abstract:
Disclosed is a novel aminopyridine derivative having excellent pharmacological activities including an excellent neuroprotective activity, an excellent neurogenesis (nerve regeneration) promotion activity and an excellent cognitive function improvement activity, preferably having low toxicity and high transferability into the central nervous system. Specifically disclosed is a compound represented by formula (I) [wherein the ring A represents a monocyclic aromatic hydrocarbon ring or the like; the ring B may have a substituent; the ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, a methylene group, or the like; X represents -NRa- or the like; Ra represents a hydrogen atom or the like; n represents 1 or 2; and R1 to R3 independently represent a hydrogen atom or the like; wherein the rings A and D may be fused to each other to form a fused ring that may have a substituent and the ring A-L- in formula (I) may bind to X, and L represents a bond when the ring A represents a pyrazole that may be substituted and the ring D represents a benzene that may be substituted] or a salt thereof.

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Inventors:
TSUKAMOTO Tetsuya (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 86, 〒5328686, JP)
塚本 徹哉 (〒86 大阪府大阪市淀川区十三本町二丁目17番85号 武田薬品工業株式会社内 Osaka, 〒5328686, JP)
WAKABAYASHI Takeshi (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 86, 〒5328686, JP)
若林 健志 (〒86 大阪府大阪市淀川区十三本町二丁目17番85号 武田薬品工業株式会社内 Osaka, 〒5328686, JP)
Application Number:
JP2010/070496
Publication Date:
May 26, 2011
Filing Date:
November 17, 2010
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1-1 Doshomachi 4-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
武田薬品工業株式会社 (〒45 大阪府大阪市中央区道修町四丁目1番1号 Osaka, 〒5410045, JP)
TSUKAMOTO Tetsuya (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 86, 〒5328686, JP)
塚本 徹哉 (〒86 大阪府大阪市淀川区十三本町二丁目17番85号 武田薬品工業株式会社内 Osaka, 〒5328686, JP)
WAKABAYASHI Takeshi (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 86, 〒5328686, JP)
International Classes:
C07D213/74; A61K31/496; A61K31/5377; A61K31/551; A61P3/10; A61P9/00; A61P9/10; A61P13/00; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D401/04; C07D405/04; C07D409/04; C07D413/04
Domestic Patent References:
2008-11-20
2008-08-21
2008-12-24
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2006-01-26
2008-08-21
2006-04-06
2007-11-15
2008-11-20
2000-06-15
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2010-09-16
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US5866562A1999-02-02
JPH09263545A1997-10-07
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See also references of EP 2502909A1
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (ABE IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome, Chuo-k, Tokyo 28, 〒1040028, JP)
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