Title:
AMINOPYRIMIDINE COMPOUND AND COMPOSITION COMPRISING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/042187
Kind Code:
A1
Abstract:
Provided are an aminopyrimidine compound as shown in formula (I), a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate or a solvate thereof, and a pharmaceutical composition comprising same and the use thereof. The aminopyrimidine compound and the composition comprising same have excellent inhibition to protein kinases, and at the same time have better pharmacokinetic parameter characteristics, and can improve the drug concentration of the compound in animals, and thereby improve the efficacy and safety of the drug.
Inventors:
WANG YIHAN (CN)
LI HUANYIN (CN)
LI HUANYIN (CN)
Application Number:
PCT/CN2018/101471
Publication Date:
March 07, 2019
Filing Date:
August 21, 2018
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D403/14; A61K31/506; A61K31/5377; A61P35/00; A61P37/02; C07D401/14; C07D405/14; C07D413/14
Domestic Patent References:
| WO2016054987A1 | 2016-04-14 | |||
| WO2017120429A1 | 2017-07-13 | |||
| WO2016060443A2 | 2016-04-21 |
Foreign References:
| CN106795144A | 2017-05-31 | |||
| CN104788427A | 2015-07-22 | |||
| US5376645A | 1994-12-27 |
Other References:
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
EDWARD B.ROCHE, ED.: "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
D. FLEISHERS. RAMONH. BARBRA: "Advanced Drug Delivery Reviews", vol. 19, 1996, article "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", pages: 115 - 130
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, EASTON
See also references of EP 3653622A4
EDWARD B.ROCHE, ED.: "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
D. FLEISHERS. RAMONH. BARBRA: "Advanced Drug Delivery Reviews", vol. 19, 1996, article "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", pages: 115 - 130
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, EASTON
See also references of EP 3653622A4
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