Title:
AMINOPYRIMIDINE HETEROCYCLIC COMPOUND WITH ADENOSINE RECEPTOR ANTAGONISTIC ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/088755
Kind Code:
A1
Abstract:
Disclosed hereinis an aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activity, comprising a compound of the general formula (I), or a pharmaceutically acceptable salt thereof. The aminopyrimidine heterocyclic compound with adenosine receptor antagonistic activitydisclosed herein can be used as an effective adenosine receptor antagonist, and can be used for the treatment or prevention of disorders caused by abnormal level of adenosine.
Inventors:
XIAOHU ZHANG (CN)
Application Number:
PCT/CN2016/106906
Publication Date:
June 01, 2017
Filing Date:
November 23, 2016
Export Citation:
Assignee:
SUZHOU YUNXUAN YIYAO KEJI YOUXIAN GONGSI (CN)
International Classes:
C07D401/14; A61K31/506; A61K31/5377; A61P11/00; A61P11/06; A61P25/00; A61P29/00; A61P35/00; C07D401/04; C07D403/04
Foreign References:
| CN103664908A | 2014-03-26 | |||
| CN1630644A | 2005-06-22 | |||
| JP2003206230A | 2003-07-22 |
Other References:
JENS-UWE PETERS ET AL.: "Aminomethylpyrimidines as novel DPP-IV inhibitors: A 100 000-fold activity increase by optimization of aromatic substituents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 6, 31 December 2004 (2004-12-31), pages 1491 - 1493, XP002397579
Z.H.YANG ET AL.: "Identification of a New Series of Potent Adenosine A2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson's Disease", ACS CHEMICAL NEUROSCIENCE, vol. 7, no. 11, 28 August 2016 (2016-08-28), pages 1575 - 1584, XP055385287
A.L.XAVIER ET AL.: "Antinociceptive pyrimidine derivatives: aqueous multicomponent microwave assisted synthesis", TETRAHEDRON LETTERS, vol. 54, no. 26, 3 May 2013 (2013-05-03), pages 3462 - 3465, XP055385288
Z.H.YANG ET AL.: "Identification of a New Series of Potent Adenosine A2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson's Disease", ACS CHEMICAL NEUROSCIENCE, vol. 7, no. 11, 28 August 2016 (2016-08-28), pages 1575 - 1584, XP055385287
A.L.XAVIER ET AL.: "Antinociceptive pyrimidine derivatives: aqueous multicomponent microwave assisted synthesis", TETRAHEDRON LETTERS, vol. 54, no. 26, 3 May 2013 (2013-05-03), pages 3462 - 3465, XP055385288
Attorney, Agent or Firm:
JIANG SU SUNDY LAW FIRM (CN)
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