Title:
AMINOPYRIMIDINES AS ALK INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2018/044767
Kind Code:
A3
Abstract:
The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, and R7 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to inhibition of ALK such as cancer.
Inventors:
WANG SHAOMENG (US)
CHEN JIANYONG (US)
CHEN JIANYONG (US)
Application Number:
PCT/US2017/048845
Publication Date:
April 12, 2018
Filing Date:
August 28, 2017
Export Citation:
Assignee:
UNIV MICHIGAN REGENTS (US)
International Classes:
C07D405/14; A61K31/506; A61P29/00; A61P35/00; A61P37/00; C07D401/12
Domestic Patent References:
WO2015130014A1 | 2015-09-03 | |||
WO2015081813A1 | 2015-06-11 | |||
WO2012106540A1 | 2012-08-09 |
Attorney, Agent or Firm:
NAPOLI, James, J. (US)
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