Title:
AMMONIA-OXIDIZING NITROSOMONAS EUTROPHA STRAIN D23
Document Type and Number:
WIPO Patent Application WO/2015/160911
Kind Code:
A3
Abstract:
This disclosure provides, inter alia, an optimized strain of Nitrosomonas eutropha (N. eutropha) designated D23, D23-100, or AOB D23-100. N. eutropha bacteria disclosed in this application have desirable properties, e.g., optimized properties, such as the ability to suppress growth of pathogenic bacteria, and an enhanced ability to produce nitric oxide and nitric oxide precursors. The N. eutropha herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
Inventors:
WHITLOCK DAVID R (US)
GRYLLOS IOANNIS (US)
JAMAS SPIROS (US)
WEISS LARRY (US)
GRYLLOS IOANNIS (US)
JAMAS SPIROS (US)
WEISS LARRY (US)
Application Number:
PCT/US2015/025909
Publication Date:
December 10, 2015
Filing Date:
April 15, 2015
Export Citation:
Assignee:
AOBIOME LLC (US)
International Classes:
A61K9/00; C12N1/00
Domestic Patent References:
| WO2003057380A2 | 2003-07-17 |
Other References:
STEIN LISA Y ET AL: "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation.", ENVIRONMENTAL MICROBIOLOGY DEC 2007, vol. 9, no. 12, December 2007 (2007-12-01), pages 2993 - 3007, XP002742354, ISSN: 1462-2912
NORTON JEANETTE M ET AL: "Diversity of ammonia monooxygenase operon in autotrophic ammonia-oxidizing bacteria", ARCHIVES OF MICROBIOLOGY, vol. 177, no. 2, February 2002 (2002-02-01), pages 139 - 149, XP002742355, ISSN: 0302-8933
SUWA Y ET AL: "PHYLOGENETIC RELATIONSHIPS OF ACTIVATED SLUDGE ISOLATES OF AMMONIA OXIDIZERS WITH DIFFERENT SENSITIVITIES TO AMMONIUM SULFATE", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, XX, XX, vol. 43, 1 January 1997 (1997-01-01), pages 373 - 379, XP001028235
NORTON JEANETTE M ET AL: "Diversity of ammonia monooxygenase operon in autotrophic ammonia-oxidizing bacteria", ARCHIVES OF MICROBIOLOGY, vol. 177, no. 2, February 2002 (2002-02-01), pages 139 - 149, XP002742355, ISSN: 0302-8933
SUWA Y ET AL: "PHYLOGENETIC RELATIONSHIPS OF ACTIVATED SLUDGE ISOLATES OF AMMONIA OXIDIZERS WITH DIFFERENT SENSITIVITIES TO AMMONIUM SULFATE", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, XX, XX, vol. 43, 1 January 1997 (1997-01-01), pages 373 - 379, XP001028235
Attorney, Agent or Firm:
ANASTASI, John, N. (Riverfront Office ParkOne Main Street, Suite 110, Cambridge MA, US)
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