Title:
AMORPHOUS IVABRADINE HYDROCHLORIDE, AND PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/026172
Kind Code:
A1
Abstract:
Disclosed are an amorphous ivabradine hydrochloride, and a preparation method therefor and uses thereof. The method for preparing the ivabradine hydrochloride comprises the following steps: dissolving ivabradine hydrochloride in water to prepare an ivabradine hydrochloride water solution, performing filtering, then taking the filtrate, and carrying out freezing-drying treatment in a vacuum condition to obtain the required amorphous ivabradine hydrochloride. The preparation method has good repetitiveness and a stable process and is suitable for industrial production, and a single amorphous ivabradine hydrochloride is prepared.
Inventors:
PENG TAO (CN)
LIU BAOJIE (CN)
GE JISHENG (CN)
LIU BAOJIE (CN)
GE JISHENG (CN)
Application Number:
PCT/CN2014/085997
Publication Date:
February 25, 2016
Filing Date:
September 05, 2014
Export Citation:
Assignee:
SUZHOU YABAO PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
C07D223/16; A61K9/20; A61K31/55
Domestic Patent References:
| WO2014102827A1 | 2014-07-03 | |||
| WO2008146308A2 | 2008-12-04 |
Foreign References:
| CN101330905A | 2008-12-24 | |||
| CN101463008A | 2009-06-24 | |||
| CN101597261A | 2009-12-09 | |||
| CN102050784A | 2011-05-11 |
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
北京三聚阳光知识产权代理有限公司 (CN)
北京三聚阳光知识产权代理有限公司 (CN)
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