Title:
AN AMORPHOUS NINTEDANIB ESYLATE AND SOLID DISPERSION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/077551
Kind Code:
A3
Abstract:
Nintedanib base polymorphic forms and processes for preparing the same. A process for the purification of nintedanib base is disclosed. An amorphous form of nintedanib and process for the preparation of the same are also disclosed. A solid dispersion of amorphous nintedanib with pharmaceutically acceptable excipients and processes for the preparation of the same are also disclosed.
Inventors:
JETTI RAMAKOTESWARA RAO (IN)
INDUKURI ANJANEYARAJU (IN)
BOMMAREDDY AGGI RAMIREDDY (IN)
SINGH AMITH (IN)
GHOSH SOUMYAJIT (IN)
JOSHI RAJESH (IN)
SHINDE DATTATRAYA (IN)
HUBLIKAR MAHESH (IN)
BHOITE SHIVAJI (IN)
INDUKURI ANJANEYARAJU (IN)
BOMMAREDDY AGGI RAMIREDDY (IN)
SINGH AMITH (IN)
GHOSH SOUMYAJIT (IN)
JOSHI RAJESH (IN)
SHINDE DATTATRAYA (IN)
HUBLIKAR MAHESH (IN)
BHOITE SHIVAJI (IN)
Application Number:
PCT/IN2016/050378
Publication Date:
June 15, 2017
Filing Date:
November 02, 2016
Export Citation:
Assignee:
MYLAN LABORATORIES LTD (IN)
International Classes:
C07D209/34
Domestic Patent References:
| WO2004013099A1 | 2004-02-12 | |||
| WO2009071523A1 | 2009-06-11 |
Other References:
ANONYMOUS: "New crystalline forms of methyl-(3Z)-3-[({4-[N-methyl-2-(4-methyl-1-piperazinyl)acetamido]phenyl}-amino)(phenyl)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate (IPCOM000210964D)", IP.COM JOURNAL, 19 September 2011 (2011-09-19), XP002767764
CAIRA: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, vol. 198, 1 January 1998 (1998-01-01), SPRINGER, BERLIN, DE, pages 163 - 208, XP008166276, ISSN: 0340-1022
CAIRA: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, vol. 198, 1 January 1998 (1998-01-01), SPRINGER, BERLIN, DE, pages 163 - 208, XP008166276, ISSN: 0340-1022
Attorney, Agent or Firm:
HASAN, Afzal et al. (IN)
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