AMORPHOUS SUBSTANCE OF IDELALISIBE AND PREPARATION METHOD THEREFOR

Title:

AMORPHOUS SUBSTANCE OF IDELALISIBE AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2016/165618

Kind Code:

A1

Abstract:

Disclosed are an amorphous substance of idelalisibe and a preparation method therefor, so as to obtain a no-sharp diffraction peak in an X-ray powder diffraction spectrum in the case of Cu-Kalpha radiation, expressed by a degree 2θ. The present invention also provides a method for preparing the amorphous substance of idelalisibe. The method is simple to operate and is easy to implement. The amorphous substance of idelalisibe in the present invention greatly increases the dissolvability of idelalisib and helps to increase the biological utilization degree of a pharmaceutical preparation; compared with the existing crystal form idelalisib, the solubility of the amorphous substance of idelalisibe in the present is obviously increased, and the amorphous substance of idelalisibe better facilitates the absorption of the medicine by the body, so that the medicine can better achieve a clinical disease treatment effect; in addition, under the condition of accelerated testing, the amorphous substance can keep good physical stability and chemical stability.

Inventors:

XIONG ZHIGANG (CN)
ZI CHUNPENG (CN)
HU TAO (CN)
ZHANG XINI (CN)

Application Number:

PCT/CN2016/079152

Publication Date:

October 20, 2016

Filing Date:

April 13, 2016

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ALNOVA PHARMACEUTICALS LTD (CN)

International Classes:

C07D473/34

Domestic Patent References:

WO2015092810A2

2015-06-25

Foreign References:

CN104892612A	2015-09-09
CN104130261A	2014-11-05
CN104262344A	2015-01-07
CN101031569A	2007-09-05
CN104334560A	2015-02-04

Other References: