AMPHIPATHIC MOLECULE, MOLECULAR AGGREGATE COMPRISING THE AMPHIPATHIC MOLECULE, AND USE OF THE MOLECULAR AGGREGATE

Title:

AMPHIPATHIC MOLECULE, MOLECULAR AGGREGATE COMPRISING THE AMPHIPATHIC MOLECULE, AND USE OF THE MOLECULAR AGGREGATE

Document Type and Number:

WIPO Patent Application WO/2008/143339

Kind Code:

A1

Abstract:

Disclosed is an amphipathic molecule having two or more zwitterionic functional groups in its hydrophilic moiety. Also disclosed is a molecular aggregate comprising the amphipathic molecule as a constituent lipid. The molecular aggregate can form a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when the vesicular structure is deformed under an acidic pH environment. The molecular aggregate can be used as a transporter for a drug, a probe, a nucleic acid, a protein or the like.

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Inventors:

TAKEOKA SHINJI (JP)
OBATA YOSUKE (JP)
TAJIMA SHOJI (JP)
ITO MANABU (JP)
MIZUNO ATSUSHI (JP)
NISHIYAMA NATSUKO (JP)
TAKEUCHI YOSHITO (JP)

Application Number:

PCT/JP2008/059499

Publication Date:

November 27, 2008

Filing Date:

May 16, 2008

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Assignee:

UNIV WASEDA (JP)
JAPAN CHEM RES (JP)
TAKEOKA SHINJI (JP)
OBATA YOSUKE (JP)
TAJIMA SHOJI (JP)
ITO MANABU (JP)
MIZUNO ATSUSHI (JP)
NISHIYAMA NATSUKO (JP)
TAKEUCHI YOSHITO (JP)

International Classes:

C07K2/00; A61K38/43; A61K47/18; A61K47/42; C07C229/16; C07C237/12; C12N15/09

Domestic Patent References:

WO2003018539A1	2003-03-06
WO2001016211A1	2001-03-08
WO2002038530A1	2002-05-16

Foreign References:

JP2005154514A	2005-06-16
JP2007210953A	2007-08-23

Other References:

D. PAPAHADJOPOULOS ET AL., BIOCHEMISTRY, vol. 24, 1985, pages 3091 - 3098
D. H. THOMPSON ET AL., LANGMUIR, vol. 19, 2003, pages 6408 - 6415
G SHI ET AL., JOURNAL OF CONTROLLED RELEASE, vol. 80, 2002, pages 309 - 319
See also references of EP 2157096A4

Attorney, Agent or Firm:

KOBAYASHI, Hiroshi et al. (IKUBO & KATAYAMAFukuoka Bldg. 9th Fl., 2-8-7, Yaes, Chuo-ku Tokyo 28, JP)

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