AMPHIPHILIC MOLECULE CONTAINING O-NITROBENZYL ESTER-BASED PHOTODEGRADABLE GROUP, AND SYNTHESIS METHOD THEREFOR

WIPO Patent Application WO/2020/220963

A1

The present invention relates to the field of surfactants. Disclosed are a novel photodegradable amphiphilic molecule and synthesis method therefor. The synthesis of the photodegradable amphiphilic molecule has five steps of reactions: (1) performing dehydration with diethylenetriaminepentaacetic acid as a raw material and acetic anhydride as a dehydrant under pyridine catalysis to generate diethylenetriaminepentaacetic dianhydride; (2) performing methylene removal on 6-nitropiperonal under the action of aluminum chloride and hydrobromic acid; (3) etherificating 4,5-dihydroxy-2-nitrobenzaldehyde with bromoalkane under an alkaline condition; (4) reducing 4,5-dihydroxy-2-nitrobenzaldehyde to 4,5-dihydroxy-2-nitrobenzyl alcohol under the action of a reductant; and (5) esterificating the 4,5-dihydroxy-2-nitrobenzyl alcohol with an excess amount of diethylenetriaminepentaacetic dianhydride to obtain an o-nitrobenzyl ester-based amphiphilic molecule. According to the present invention, the reaction condition of an o-nitrobenzyl alcohol and diethylenetriaminepentaacetic dianhydride is mild, and the use of an excess amount of diethylenetriaminepentaacetic dianhydride reduces the occurrence of a side reaction. The amphiphilic molecule has good ultraviolet degradation performance.

QIAO WEIHONG (CN)
YAO WEIHE (CN)
LIU CHENYU (CN)
WANG NING (CN)
ZHOU HENGJUN (CN)
YU SIMIAO (CN)
WANG XINMENG (CN)

PCT/CN2020/083949

November 05, 2020

April 09, 2020

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UNIV DALIAN TECH (CN)

C07C229/16; A61K9/127; A61K47/18; C07C227/18

CN110003031A	2019-07-12
CN105833791A	2016-08-10
CN108059619A	2018-05-22

DALIAN EAST PATENT AGENT LTD. (CN)

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