Title:
AMPHIPHILIC PEPTIDE AND ANALOGS THEREOF AMPHIPHILIC PEPTIDE AND ANALOGS THEREOF
Document Type and Number:
WIPO Patent Application WO1996028468
Kind Code:
A3
Abstract:
The invention relates to amphiphilic peptides and analogs thereof. The specification defines the molecules in three ways and discloses that antimicrobial peptides which comprise a sequence selected from the group comprising: +-++--++--+--++, +-++--++---+-+++, ++-+++-++-+++--, ++-+++-++-++++-++-, ++-+++-++--++--++-, --++--++-++--++-++, ++++-+++--+--++, ++-+++++++-++-++--, wherein + indicates a hydrophobic amino acid residue and - indicates a hydrophilic amino acid residue have improved antimicrobial properties. Specific sequences of active peptides are given. The specification also discloses two general equations which define the rule by whicc peptides falling within the scope of the invention are identified.
Inventors:
BHAKOO MANMOHAN (GB)
PATEL SHAIL (GB)
STOTT PETER IAN (GB)
PATEL SHAIL (GB)
STOTT PETER IAN (GB)
Application Number:
PCT/EP1996/000844
Publication Date:
April 17, 1997
Filing Date:
February 27, 1996
Export Citation:
Assignee:
UNILEVER PLC (GB)
UNILEVER NV (GB)
BHAKOO MANMOHAN (GB)
PATEL SHAIL (GB)
STOTT PETER IAN (GB)
UNILEVER NV (GB)
BHAKOO MANMOHAN (GB)
PATEL SHAIL (GB)
STOTT PETER IAN (GB)
International Classes:
A01N37/46; C07K7/08; C07K14/46; A61K38/00; (IPC1-7): C07K14/00; A61L2/16; C07K7/00
Domestic Patent References:
| WO1992001462A1 | 1992-02-06 | |||
| WO1994012206A1 | 1994-06-09 | |||
| WO1994013697A1 | 1994-06-23 | |||
| WO1994019369A1 | 1994-09-01 | |||
| WO1991012015A1 | 1991-08-22 |
Foreign References:
| US5294605A | 1994-03-15 | |||
| US5221732A | 1993-06-22 | |||
| US5239059A | 1993-08-24 | |||
| US5225399A | 1993-07-06 |
Other References:
BLONDELLE S.E. ET AL.: "Evaluation of peptide-peptide interactions using reversed phase high-performance liquid chromatographgy", JOURNAL OF CHROMATOGRAPHY, vol. 625, 20 November 1992 (1992-11-20), AMSTERDAM NL, pages 199 - 206, XP000573322
SCHNEIDER G. ET AL.: "Artificial neural networks and simulated molecular evolution are potential tools for sequence-oriented protein design", CABIOS COMPUTER APPLICATIONS IN THE BIOSCIENCES, vol. 10, no. 6, December 1994 (1994-12-01), OXFORD GB, pages 635 - 645, XP000608600
SCHNEIDER G. ET AL.: "Development of simple fitness landscapes for peptides by artificial neural filter systems", BIOLOGICAL CYBERNETICS, vol. 73, no. 3, August 1995 (1995-08-01), HEIDELBERG DE, pages 245 - 254, XP000525997
SCHNEIDER G. ET AL.: "Artificial neural networks and simulated molecular evolution are potential tools for sequence-oriented protein design", CABIOS COMPUTER APPLICATIONS IN THE BIOSCIENCES, vol. 10, no. 6, December 1994 (1994-12-01), OXFORD GB, pages 635 - 645, XP000608600
SCHNEIDER G. ET AL.: "Development of simple fitness landscapes for peptides by artificial neural filter systems", BIOLOGICAL CYBERNETICS, vol. 73, no. 3, August 1995 (1995-08-01), HEIDELBERG DE, pages 245 - 254, XP000525997
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