Title:
AMPHIPHILIC POLY(AMINO ACID), BLOCK COPOLYMER USING THE AMPHIPHILIC POLY(AMINO ACID), AND COMPLEX INCLUDING THE AMPHIPHILIC POLY(AMINO ACID) OR THE BLOCK COPOLYMER AND NUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2020/067142
Kind Code:
A1
Abstract:
The present invention provides an amphiphilic poly(amino acid) for nucleic acid delivery, which is represented by the following formula (1): where: R1 represents a hydroxy group, an oxybenzyl group, an -O-R1a group, or an -NH-R1b group, where R1a and R1b each independently represent an unsubstituted or substituted, linear or branched alkyl group having 1 to 12 carbon atoms; R2 represents a hydrogen atom, an unsubstituted or substituted, linear or branched alkyl group having 1 to 12 carbon atoms, or an unsubstituted or substituted, linear or branched alkylcarbonyl group having 1 to 24 carbon atoms; R3a, R3b, R4a, and R4b each independently represent a methylene group or an ethylene group; R5a and R5b each independently represent -O- or -NH-; R6a and R6b each independently represent an unsubstituted or substituted aliphatic hydrocarbon group having 7 to 12 carbon atoms that may contain an alicycle; R7a and R7b are each independently selected from groups identical to or different from each other in the group consisting of the following groups: -NH-(CH2)p1-[NH-(CH2)q1-]r1NH2 (i); -NH-(CH2)p2-N[-(CH2)q2-NH2]2 (ii); -NH-(CH2)p3-N{[-(CH2)q3-NH2][-(CH2)q4-NH-]r2H} (iii); and -NH-(CH2)p4-N{-(CH2)q5-N[-(CH2)q6-NH2]2}2 (iv), where p1 to p4, q1 to q6, and r1 and r2 each independently represent an integer of from 1 to 5; R8 represents a side chain of an amino acid selected from the group consisting of ornithine, lysine, homolysine, arginine, homoarginine, and histidine; m represents an integer of 9 or more; n represents an integer of from 0 to m; x represents an integer of from 2 to 300; y represents an integer of from 0 to x; and z represents an integer of from 0 to x, provided that a relationship of y+z≦x and a relationship of 11≦m+x≦400 are satisfied, and repeating units in the formula (1) may be randomly present.
Inventors:
KIM HYUNJIN (JP)
MIYATA KANJIRO (JP)
KATAOKA KAZUNORI (JP)
MIYATA KANJIRO (JP)
KATAOKA KAZUNORI (JP)
Application Number:
PCT/JP2019/037555
Publication Date:
April 02, 2020
Filing Date:
September 25, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07K14/00; A61K47/34; A61K47/62; C08G69/10; C08L77/04; A61K31/7105; A61K48/00
Domestic Patent References:
| WO2017056095A1 | 2017-04-06 |
Foreign References:
| US20120149649A1 | 2012-06-14 |
Other References:
See also references of EP 3856759A4
Attorney, Agent or Firm:
MOMII Takafumi (JP)
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