Title:
AMPHIPHILIC POLYSACCHARDIDES,POLYSACCHARIDE-BASED HYDROGELS, AND METHODS OF MANUFACTURE
Document Type and Number:
WIPO Patent Application WO/2019/140304
Kind Code:
A1
Abstract:
A method for the synthesis of alkyl co-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the co-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.
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Inventors:
EDGAR KEVIN (US)
NICHOLS BRITTANY (US)
CHEN JUNYI (US)
FRAZIER CHARLES (US)
TAYLOR LYNNE (US)
MOSQUERA-GIRALDO LAURA (US)
NORRIS ANN (US)
ADAMS BENJAMIN (US)
NICHOLS BRITTANY (US)
CHEN JUNYI (US)
FRAZIER CHARLES (US)
TAYLOR LYNNE (US)
MOSQUERA-GIRALDO LAURA (US)
NORRIS ANN (US)
ADAMS BENJAMIN (US)
Application Number:
PCT/US2019/013354
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
VIRGINA TECH INTELLECTUAL PROPERTIES INC (US)
EDGAR KEVIN (US)
NICHOLS BRITTANY L B (US)
CHEN JUNYI (US)
FRAZIER CHARLES (US)
TAYLOR LYNNE S (US)
MOSQUERA GIRALDO LAURA I (US)
NORRIS ANN (US)
ADAMS BENJAMIN (US)
EDGAR KEVIN (US)
NICHOLS BRITTANY L B (US)
CHEN JUNYI (US)
FRAZIER CHARLES (US)
TAYLOR LYNNE S (US)
MOSQUERA GIRALDO LAURA I (US)
NORRIS ANN (US)
ADAMS BENJAMIN (US)
International Classes:
C08B3/20; C08B3/22; C08B15/04
Domestic Patent References:
| WO2008007153A2 | 2008-01-17 |
Foreign References:
| US3769247A | 1973-10-30 | |||
| US7879994B2 | 2011-02-01 | |||
| US20140378532A1 | 2014-12-25 |
Other References:
TITCOMBE, LA.: "Chemically modified cotton liners: preparation and paper making properties", THESIS, July 1992 (1992-07-01), Tasmania University, pages 1 - 269, XP055624679, Retrieved from the Internet [retrieved on 20190222]
KOSCHELLA, A ET AL.: "Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate: Preparation, Characterization, and Properties", MACROMOLECULAR BIOSCIENCE, vol. 8, no. 1, 2008, pages 96 - 105, XP055624685
KOSCHELLA, A ET AL.: "Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate: Preparation, Characterization, and Properties", MACROMOLECULAR BIOSCIENCE, vol. 8, no. 1, 2008, pages 96 - 105, XP055624685
Attorney, Agent or Firm:
MAYBERRY, Michele, L. (US)
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