Title:
AMPHIPOLS
Document Type and Number:
WIPO Patent Application WO/2020/115083
Kind Code:
A3
Abstract:
The invention relates to polymeric compounds of formula (I) which allow the solubilization and/or stabilization of membrane proteins. The invention relates in particular to the complexes which said compounds form with membrane proteins and to the method for the solubilization and/or stabilization of a membrane protein comprising the use of said compounds.
Inventors:
GIUSTI FABRICE (FR)
MARCONNET ANAÏS (FR)
ZOONENS MANUELA (FR)
MARCONNET ANAÏS (FR)
ZOONENS MANUELA (FR)
Application Number:
PCT/EP2019/083563
Publication Date:
July 30, 2020
Filing Date:
December 03, 2019
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV PARIS (FR)
UNIV PARIS (FR)
International Classes:
C08F220/06; C08F8/32; C08F8/44; C08F220/56; G01N33/68; C08F120/06
Domestic Patent References:
| WO1997008217A1 | 1997-03-06 |
Foreign References:
| JP2003262728A | 2003-09-19 | |||
| JPH04138449A | 1992-05-12 | |||
| US4921903A | 1990-05-01 |
Other References:
ALAN F TOMINEY ET AL: "RAFT polymers for protein recognition", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 6, 28 May 2010 (2010-05-28), XP055697388, DOI: 10.3762/bjoc.6.66
F. VIAL ET AL: "Rate of Permeabilization of Giant Vesicles by Amphiphilic Polyacrylates Compared to the Adsorption of These Polymers onto Large Vesicles and Tethered Lipid Bilayers", LANGMUIR, vol. 25, no. 13, 7 July 2009 (2009-07-07), US, pages 7506 - 7513, XP055592478, ISSN: 0743-7463, DOI: 10.1021/la900261s
JI YANFENG ET AL: "The relationships between rheological rules and cohesive energy of amphiphilic polymers with different hydrophobic groups", JOURNAL OF POLYMER RESEARCH, SPRINGER NETHERLANDS, NL, vol. 22, no. 3, 3 February 2015 (2015-02-03), pages 1 - 7, XP035468879, ISSN: 1022-9760, [retrieved on 20150203], DOI: 10.1007/S10965-015-0669-7
TRIBET C ET AL: "AMPHIPOLS: POLYMERS THAT KEEP MEMBRANE PROTEINS SOLUBLE IN AQUEOUS SOLUTIONS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATIONAL ACADEMY OF SCIENCES, US, vol. 93, no. 26, December 1996 (1996-12-01), pages 15047 - 15050, XP002038264, ISSN: 0027-8424, DOI: 10.1073/PNAS.93.26.15047
LE BON CHRISTEL ET AL: "Labeling and Functionalizing Amphipols for Biological Applications", JOURNAL OF MEMBRANE BIOLOGY, SPRINGER NEW YORK LLC, US, vol. 247, no. 9, 3 April 2014 (2014-04-03), pages 797 - 814, XP036324045, ISSN: 0022-2631, [retrieved on 20140403], DOI: 10.1007/S00232-014-9655-Y
F. VIAL ET AL: "Rate of Permeabilization of Giant Vesicles by Amphiphilic Polyacrylates Compared to the Adsorption of These Polymers onto Large Vesicles and Tethered Lipid Bilayers", LANGMUIR, vol. 25, no. 13, 7 July 2009 (2009-07-07), US, pages 7506 - 7513, XP055592478, ISSN: 0743-7463, DOI: 10.1021/la900261s
JI YANFENG ET AL: "The relationships between rheological rules and cohesive energy of amphiphilic polymers with different hydrophobic groups", JOURNAL OF POLYMER RESEARCH, SPRINGER NETHERLANDS, NL, vol. 22, no. 3, 3 February 2015 (2015-02-03), pages 1 - 7, XP035468879, ISSN: 1022-9760, [retrieved on 20150203], DOI: 10.1007/S10965-015-0669-7
TRIBET C ET AL: "AMPHIPOLS: POLYMERS THAT KEEP MEMBRANE PROTEINS SOLUBLE IN AQUEOUS SOLUTIONS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATIONAL ACADEMY OF SCIENCES, US, vol. 93, no. 26, December 1996 (1996-12-01), pages 15047 - 15050, XP002038264, ISSN: 0027-8424, DOI: 10.1073/PNAS.93.26.15047
LE BON CHRISTEL ET AL: "Labeling and Functionalizing Amphipols for Biological Applications", JOURNAL OF MEMBRANE BIOLOGY, SPRINGER NEW YORK LLC, US, vol. 247, no. 9, 3 April 2014 (2014-04-03), pages 797 - 814, XP036324045, ISSN: 0022-2631, [retrieved on 20140403], DOI: 10.1007/S00232-014-9655-Y
Attorney, Agent or Firm:
A.P.I. CONSEIL (FR)
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