AMPLIFICATION OF NUCLEIC ACIDS WITH ELECTRONIC DETECTION

Title:

AMPLIFICATION OF NUCLEIC ACIDS WITH ELECTRONIC DETECTION

Document Type and Number:

WIPO Patent Application WO1999037819

Kind Code:

A3

Abstract:

The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.

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Inventors:

KAYYEM JON FAIZ (US)

Application Number:

PCT/US1999/001705

Publication Date:

October 14, 1999

Filing Date:

January 27, 1999

Export Citation:

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Assignee:

CLINICAL MICRO SENSORS INC (US)
KAYYEM JON FAIZ (US)

International Classes:

B01D17/02; B01D24/10; B01D35/12; C02F1/28; C12Q1/68; G01N27/30; G01N27/416; (IPC1-7): C12Q1/68

Domestic Patent References:

WO1996040712A1	1996-12-19
WO1997009337A1	1997-03-13
WO1998020162A2	1998-05-14
WO1998057159A1	1998-12-17

Other References:

UTO Y ET AL: "Electrochemical analysis of DNA amplified by the polymerase chain reaction with a ferrocenylated oligonucleotide", ANALYTICAL BIOCHEMISTRY, vol. 250, no. 250, 1997, pages 122 - 124 124, XP002106964, ISSN: 0003-2697

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