Title:
AMYLOID β PROTEIN AGGREGATION INHIBITOR, DIAGNOSTIC AGENT FOR ABNORMALITY OF AMYLOID β PROTEIN, AND DIAGNOSTIC KIT FOR ABNORMALITY OF AMYLOID β PROTEIN
Document Type and Number:
WIPO Patent Application WO/2006/083019
Kind Code:
A1
Abstract:
Disclosed is an amyloid β protein aggregation inhibitor. The inhibitor comprises a compound represented by the chemical structure composed of a monosaccharide or a sugar chain having two or more monosaccharides, wherein a part or all of the OH groups are substituted by (i) a sulfo group or a salt of a sulfo group and (ii) a hydrophobic group and a part or all of the remainder of the substituted OH groups may be substituted by a group selected from H, NH2, NHR6 and NHR6R7. Particularly preferably, the inhibitor is a compound represented by the general formula (1).
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Inventors:
MIURA YOSHIKO (JP)
KOIKE MIHOKO (JP)
NISHIDA YOSHIHIRO (JP)
KOBAYASHI KAZUKIYO (JP)
KOIKE MIHOKO (JP)
NISHIDA YOSHIHIRO (JP)
KOBAYASHI KAZUKIYO (JP)
Application Number:
PCT/JP2006/302281
Publication Date:
August 10, 2006
Filing Date:
February 02, 2006
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
MIURA YOSHIKO (JP)
KOIKE MIHOKO (JP)
NISHIDA YOSHIHIRO (JP)
KOBAYASHI KAZUKIYO (JP)
MIURA YOSHIKO (JP)
KOIKE MIHOKO (JP)
NISHIDA YOSHIHIRO (JP)
KOBAYASHI KAZUKIYO (JP)
International Classes:
A61K31/7034; A61P25/28; A61P43/00; C07H15/203
Domestic Patent References:
| WO2005118609A2 | 2005-12-15 | |||
| WO2004007515A1 | 2004-01-22 | |||
| WO2005077382A1 | 2005-08-25 |
Foreign References:
| JP2001322935A | 2001-11-20 | |||
| JP2005015451A | 2005-01-20 | |||
| JP2002506043A | 2002-02-26 | |||
| JP2001513569A | 2001-09-04 |
Other References:
YASUDA K. ET AL.: "Ryusankato to Amyloid beta Tanpakushitsu no Sogo Sayo Kaiseki. (Analysis of the interaction between sulfonated sugars and Alzheimer A beta)", POLYMER REPRINTS, JAPAN, vol. 54, no. 1, 2005, pages 2169, XP003001575
YASUDA K. ET AL.: "Ryusankato to Gishusei Peptide no Sogo Sayo Kaiseki. [The interaction of sulfonated sugars with amyloid peptide of A beta (1-42) and PrP (106-126)]", POLYMER REPRINTS, vol. 54, no. 2, 2005, pages 4967, XP003001576
BAURES P.W. ET AL.: "Discovering Transthyretin Amyloid Fibril Inhibitors by Limited Screening", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1998, pages 1389 - 1401, XP002353902
KAMBARA M. ET AL.: "6-i Ryusanka N-Acetylglucosamine Cluster no Ijo Prion Sansei Sogai Kassei. (Chemical Remodeling of Glycosaminoglycans Inhibitory Activity of Sulfonated GlcNAc Derivatives against Sialdases and Scrapie Prions)", POLYMER REPRINTS, JAPAN, vol. 53, no. 1, 2004, pages 1894, XP003001577
YASUDA K. ET AL.: "Ryusankato to Gishusei Peptide no Sogo Sayo Kaiseki. [The interaction of sulfonated sugars with amyloid peptide of A beta (1-42) and PrP (106-126)]", POLYMER REPRINTS, vol. 54, no. 2, 2005, pages 4967, XP003001576
BAURES P.W. ET AL.: "Discovering Transthyretin Amyloid Fibril Inhibitors by Limited Screening", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1998, pages 1389 - 1401, XP002353902
KAMBARA M. ET AL.: "6-i Ryusanka N-Acetylglucosamine Cluster no Ijo Prion Sansei Sogai Kassei. (Chemical Remodeling of Glycosaminoglycans Inhibitory Activity of Sulfonated GlcNAc Derivatives against Sialdases and Scrapie Prions)", POLYMER REPRINTS, JAPAN, vol. 53, no. 1, 2004, pages 1894, XP003001577
Attorney, Agent or Firm:
Ohkawa, Hiroshi (Nakamura-ku Nagoya-shi, Aichi 02, JP)
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